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Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis
We examined the role of the antiapoptotic molecule Bcl-2 in combating the proapoptotic molecule Bim in control of naive and memory T cell homeostasis using Bcl-2(−/−) mice that were additionally deficient in one or both alleles of Bim. Naive T cells were significantly decreased in Bim(+/−)Bcl-2(−/−)...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118628/ https://www.ncbi.nlm.nih.gov/pubmed/17591857 http://dx.doi.org/10.1084/jem.20070618 |