Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function

It has been suggested that T cell immunoglobulin mucin (Tim)-1 expressed on T cells serves to positively costimulate T cell responses. However, crosslinking of Tim-1 by its ligand Tim-4 resulted in either activation or inhibition of T cell responses, thus raising the issue of whether Tim-1 can have...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Sheng, Najafian, Nader, Reddy, Jay, Albin, Monica, Zhu, Chen, Jensen, Eric, Imitola, Jaime, Korn, Thomas, Anderson, Ana C., Zhang, Zheng, Gutierrez, Cristina, Moll, Thomas, Sobel, Raymond A., Umetsu, Dale T., Yagita, Hideo, Akiba, Hisaya, Strom, Terry, Sayegh, Mohamed H., DeKruyff, Rosemarie H., Khoury, Samia J., Kuchroo, Vijay K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118637/
https://www.ncbi.nlm.nih.gov/pubmed/17606630
http://dx.doi.org/10.1084/jem.20062498

Ejemplares similares

Ejemplares similares