A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets

Leukocyte and platelet integrins rapidly alter their affinity and adhesiveness in response to various activation (inside-out) signals. A rare leukocyte adhesion deficiency (LAD), LAD-III, is associated with severe defects in leukocyte and platelet integrin activation. We report two new LAD cases in...

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Detalles Bibliográficos
Autores principales: Pasvolsky, Ronit, Feigelson, Sara W., Kilic, Sara Sebnem, Simon, Amos J., Tal-Lapidot, Guy, Grabovsky, Valentin, Crittenden, Jill R., Amariglio, Ninette, Safran, Michal, Graybiel, Ann M., Rechavi, Gideon, Ben-Dor, Shifra, Etzioni, Amos, Alon, Ronen
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118641/
https://www.ncbi.nlm.nih.gov/pubmed/17576779
http://dx.doi.org/10.1084/jem.20070058

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