DNA polymerase β is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts cytosines to uracils in switch (S) regions. Subsequent excision of dU by uracil DNA glycosylase (UNG) of the base excision repair (BER) pathway is required to obtain doubl...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xiaoming, Stavnezer, Janet
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118644/
https://www.ncbi.nlm.nih.gov/pubmed/17591858
http://dx.doi.org/10.1084/jem.20070756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118644/
https://www.ncbi.nlm.nih.gov/pubmed/17591858
http://dx.doi.org/10.1084/jem.20070756

Ejemplares similares