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Oral tolerance: is it all retinoic acid?
Oral tolerance has been argued to depend on “special” presentation of antigen in the gut. New studies support this idea by showing that the catalysis of vitamin A into retinoic acid (RA) in gut-associated dendritic cells (DCs) enhances the transforming growth factor (TGF)-β–dependent conversion of n...
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| Formato: | Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118658/ https://www.ncbi.nlm.nih.gov/pubmed/17620364 http://dx.doi.org/10.1084/jem.20071251 |
| _version_ | 1782141077678981120 |
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| author | von Boehmer, Harald |
| author_facet | von Boehmer, Harald |
| author_sort | von Boehmer, Harald |
| collection | PubMed |
| description | Oral tolerance has been argued to depend on “special” presentation of antigen in the gut. New studies support this idea by showing that the catalysis of vitamin A into retinoic acid (RA) in gut-associated dendritic cells (DCs) enhances the transforming growth factor (TGF)-β–dependent conversion of naive T cells into regulatory T (T reg) cells and also directs T reg cell homing to the gut. These results reveal new tolerance mechanisms that will aid the use of T reg cells in the clinic. |
| format | Text |
| id | pubmed-2118658 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2007 |
| publisher | The Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-21186582008-02-06 Oral tolerance: is it all retinoic acid? von Boehmer, Harald J Exp Med Commentaries Oral tolerance has been argued to depend on “special” presentation of antigen in the gut. New studies support this idea by showing that the catalysis of vitamin A into retinoic acid (RA) in gut-associated dendritic cells (DCs) enhances the transforming growth factor (TGF)-β–dependent conversion of naive T cells into regulatory T (T reg) cells and also directs T reg cell homing to the gut. These results reveal new tolerance mechanisms that will aid the use of T reg cells in the clinic. The Rockefeller University Press 2007-08-06 /pmc/articles/PMC2118658/ /pubmed/17620364 http://dx.doi.org/10.1084/jem.20071251 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | Commentaries von Boehmer, Harald Oral tolerance: is it all retinoic acid? |
| title | Oral tolerance: is it all retinoic acid? |
| title_full | Oral tolerance: is it all retinoic acid? |
| title_fullStr | Oral tolerance: is it all retinoic acid? |
| title_full_unstemmed | Oral tolerance: is it all retinoic acid? |
| title_short | Oral tolerance: is it all retinoic acid? |
| title_sort | oral tolerance: is it all retinoic acid? |
| topic | Commentaries |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118658/ https://www.ncbi.nlm.nih.gov/pubmed/17620364 http://dx.doi.org/10.1084/jem.20071251 |
| work_keys_str_mv | AT vonboehmerharald oraltoleranceisitallretinoicacid |