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A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNA(K164) modification

B cells use translesion DNA synthesis (TLS) to introduce somatic mutations around genetic lesions caused by activation-induced cytidine deaminase. Monoubiquitination at lysine(164) of proliferating cell nuclear antigen (PCNA(K164)) stimulates TLS. To determine the role of PCNA(K164) modifications in...

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Detalles Bibliográficos
Autores principales:	Langerak, Petra, Nygren, Anders O.H., Krijger, Peter H.L., van den Berk, Paul C.M., Jacobs, Heinz
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118671/ https://www.ncbi.nlm.nih.gov/pubmed/17664295 http://dx.doi.org/10.1084/jem.20070902

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