Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia

Specific mutations in the human gene encoding the Wiskott-Aldrich syndrome protein (WASp) that compromise normal auto-inhibition of WASp result in unregulated activation of the actin-related protein 2/3 complex and increased actin polymerizing activity. These activating mutations are associated with...

Descripción completa

Detalles Bibliográficos
Autores principales: Moulding, Dale A., Blundell, Michael P., Spiller, David G., White, Michael R.H., Cory, Giles O., Calle, Yolanda, Kempski, Helena, Sinclair, Jo, Ancliff, Phil J., Kinnon, Christine, Jones, Gareth E., Thrasher, Adrian J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118706/
https://www.ncbi.nlm.nih.gov/pubmed/17724125
http://dx.doi.org/10.1084/jem.20062324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118706/
https://www.ncbi.nlm.nih.gov/pubmed/17724125
http://dx.doi.org/10.1084/jem.20062324

Ejemplares similares