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Interleukin-10 production by effector T cells: Th1 cells show self control
Interleukin (IL)-10 is a cytokine that modulates both innate and adaptive immunity, primarily by exerting antiinflammatory effects. IL-10 was originally thought to be produced only by T helper (Th)2 cells, but is now known to be made by a variety of cell types. During many infections, CD4(+) T cells...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118719/ https://www.ncbi.nlm.nih.gov/pubmed/17296790 http://dx.doi.org/10.1084/jem.20070104 |
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author | Trinchieri, Giorgio |
author_facet | Trinchieri, Giorgio |
author_sort | Trinchieri, Giorgio |
collection | PubMed |
description | Interleukin (IL)-10 is a cytokine that modulates both innate and adaptive immunity, primarily by exerting antiinflammatory effects. IL-10 was originally thought to be produced only by T helper (Th)2 cells, but is now known to be made by a variety of cell types. During many infections, CD4(+) T cells produce both interferon (IFN)-γ, the signature Th1 cytokine, and IL-10. New data now show that the IL-10 produced by effector Th1 cells helps limit the collateral damage caused by exaggerated inflammation. But this control may also limit the effectiveness of the immune response, resulting in a failure to fully eliminate pathogens. |
format | Text |
id | pubmed-2118719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21187192007-12-13 Interleukin-10 production by effector T cells: Th1 cells show self control Trinchieri, Giorgio J Exp Med Commentaries Interleukin (IL)-10 is a cytokine that modulates both innate and adaptive immunity, primarily by exerting antiinflammatory effects. IL-10 was originally thought to be produced only by T helper (Th)2 cells, but is now known to be made by a variety of cell types. During many infections, CD4(+) T cells produce both interferon (IFN)-γ, the signature Th1 cytokine, and IL-10. New data now show that the IL-10 produced by effector Th1 cells helps limit the collateral damage caused by exaggerated inflammation. But this control may also limit the effectiveness of the immune response, resulting in a failure to fully eliminate pathogens. The Rockefeller University Press 2007-02-19 /pmc/articles/PMC2118719/ /pubmed/17296790 http://dx.doi.org/10.1084/jem.20070104 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Commentaries Trinchieri, Giorgio Interleukin-10 production by effector T cells: Th1 cells show self control |
title | Interleukin-10 production by effector T cells: Th1 cells show self control |
title_full | Interleukin-10 production by effector T cells: Th1 cells show self control |
title_fullStr | Interleukin-10 production by effector T cells: Th1 cells show self control |
title_full_unstemmed | Interleukin-10 production by effector T cells: Th1 cells show self control |
title_short | Interleukin-10 production by effector T cells: Th1 cells show self control |
title_sort | interleukin-10 production by effector t cells: th1 cells show self control |
topic | Commentaries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118719/ https://www.ncbi.nlm.nih.gov/pubmed/17296790 http://dx.doi.org/10.1084/jem.20070104 |
work_keys_str_mv | AT trinchierigiorgio interleukin10productionbyeffectortcellsth1cellsshowselfcontrol |