Circular DNA resulting from recombination between V-(D)-J joining signals and switch repetitive sequences in mouse thymocytes

During the course of analyzing circular DNA in mouse thymocytes, novel recombinants were identified with immunoglobulin heavy chain joining gene and switch region probes. These circles represent excision products of recombination between the heptamer-nonamer motif for V-(D)- J joining and a repetiti...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1991
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118817/
https://www.ncbi.nlm.nih.gov/pubmed/1900083
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collection PubMed
description During the course of analyzing circular DNA in mouse thymocytes, novel recombinants were identified with immunoglobulin heavy chain joining gene and switch region probes. These circles represent excision products of recombination between the heptamer-nonamer motif for V-(D)- J joining and a repetitive sequence for class switching. The molecular mechanisms that generate "hybrid circles" are discussed.
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spelling pubmed-21188172008-04-17 Circular DNA resulting from recombination between V-(D)-J joining signals and switch repetitive sequences in mouse thymocytes J Exp Med Articles During the course of analyzing circular DNA in mouse thymocytes, novel recombinants were identified with immunoglobulin heavy chain joining gene and switch region probes. These circles represent excision products of recombination between the heptamer-nonamer motif for V-(D)- J joining and a repetitive sequence for class switching. The molecular mechanisms that generate "hybrid circles" are discussed. The Rockefeller University Press 1991-03-01 /pmc/articles/PMC2118817/ /pubmed/1900083 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Circular DNA resulting from recombination between V-(D)-J joining signals and switch repetitive sequences in mouse thymocytes
title Circular DNA resulting from recombination between V-(D)-J joining signals and switch repetitive sequences in mouse thymocytes
title_full Circular DNA resulting from recombination between V-(D)-J joining signals and switch repetitive sequences in mouse thymocytes
title_fullStr Circular DNA resulting from recombination between V-(D)-J joining signals and switch repetitive sequences in mouse thymocytes
title_full_unstemmed Circular DNA resulting from recombination between V-(D)-J joining signals and switch repetitive sequences in mouse thymocytes
title_short Circular DNA resulting from recombination between V-(D)-J joining signals and switch repetitive sequences in mouse thymocytes
title_sort circular dna resulting from recombination between v-(d)-j joining signals and switch repetitive sequences in mouse thymocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118817/
https://www.ncbi.nlm.nih.gov/pubmed/1900083

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