Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes

Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling type 1 diabetes mellitus in man. They also exhibit lifelong T cell deficiency. The segregation of both diabetes and lymphopenia was studied in crosses between this inbred line of rats and the related but nondiabe...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1991
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118894/
https://www.ncbi.nlm.nih.gov/pubmed/2056281
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description Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling type 1 diabetes mellitus in man. They also exhibit lifelong T cell deficiency. The segregation of both diabetes and lymphopenia was studied in crosses between this inbred line of rats and the related but nondiabetic and nonlymphopenic inbred diabetes- resistant (DR) BB rat line. Diabetes segregated as a single, autosomal recessive trait and was always accompanied by lymphopenia. Among the limited number of differences in the genomic DNA sequences of the two lines, DP and DR BB, one may account for the development of diabetes and lymphopenia in the DP BB rats. It may be possible to screen the genomic DNA for such differences to detect a marker for the phenotypes.
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spelling pubmed-21188942008-04-17 Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes J Exp Med Articles Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling type 1 diabetes mellitus in man. They also exhibit lifelong T cell deficiency. The segregation of both diabetes and lymphopenia was studied in crosses between this inbred line of rats and the related but nondiabetic and nonlymphopenic inbred diabetes- resistant (DR) BB rat line. Diabetes segregated as a single, autosomal recessive trait and was always accompanied by lymphopenia. Among the limited number of differences in the genomic DNA sequences of the two lines, DP and DR BB, one may account for the development of diabetes and lymphopenia in the DP BB rats. It may be possible to screen the genomic DNA for such differences to detect a marker for the phenotypes. The Rockefeller University Press 1991-07-01 /pmc/articles/PMC2118894/ /pubmed/2056281 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes
title Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes
title_full Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes
title_fullStr Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes
title_full_unstemmed Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes
title_short Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes
title_sort diabetes segregates as a single locus in crosses between inbred bb rats prone or resistant to diabetes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118894/
https://www.ncbi.nlm.nih.gov/pubmed/2056281

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