Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis

18 cloned T cell lines reactive with Borrelia burgdorferi proteins, all CD3+4+8-TCR-alpha/beta+ and restricted by HLA class II proteins, were isolated from four patients with chronic Lyme arthritis. Analysis of these T cell clones indicated that the T cell response to the Lyme disease spirochete is...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1991
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118948/
https://www.ncbi.nlm.nih.gov/pubmed/1831490
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description 18 cloned T cell lines reactive with Borrelia burgdorferi proteins, all CD3+4+8-TCR-alpha/beta+ and restricted by HLA class II proteins, were isolated from four patients with chronic Lyme arthritis. Analysis of these T cell clones indicated that the T cell response to the Lyme disease spirochete is not oligoclonally restricted; yet all produced the same pattern of lymphokines, resembling that of murine type 1 T helper cells, after antigen-specific or nonspecific stimulation. Therefore, a subset of human CD4+ T cells, with a distinct profile of lymphokine secretion, is selectively activated by the pathogen inciting this chronic inflammatory disease.
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spelling pubmed-21189482008-04-17 Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis J Exp Med Articles 18 cloned T cell lines reactive with Borrelia burgdorferi proteins, all CD3+4+8-TCR-alpha/beta+ and restricted by HLA class II proteins, were isolated from four patients with chronic Lyme arthritis. Analysis of these T cell clones indicated that the T cell response to the Lyme disease spirochete is not oligoclonally restricted; yet all produced the same pattern of lymphokines, resembling that of murine type 1 T helper cells, after antigen-specific or nonspecific stimulation. Therefore, a subset of human CD4+ T cells, with a distinct profile of lymphokine secretion, is selectively activated by the pathogen inciting this chronic inflammatory disease. The Rockefeller University Press 1991-09-01 /pmc/articles/PMC2118948/ /pubmed/1831490 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis
title Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis
title_full Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis
title_fullStr Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis
title_full_unstemmed Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis
title_short Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis
title_sort borrelia burgdorferi activates a t helper type 1-like t cell subset in lyme arthritis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118948/
https://www.ncbi.nlm.nih.gov/pubmed/1831490

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