T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion

The severe combined immunodeficiency (SCID) mutation has been postulated to affect a V(D)J recombinase activity involved in coding joint formation. Analysis of 38 joints from 34 distinct sequences of normally rearranged T cell receptor (TCR) gamma and delta genes from adult, SCID thymocytes reveals...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1991
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118963/
https://www.ncbi.nlm.nih.gov/pubmed/1655945
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description The severe combined immunodeficiency (SCID) mutation has been postulated to affect a V(D)J recombinase activity involved in coding joint formation. Analysis of 38 joints from 34 distinct sequences of normally rearranged T cell receptor (TCR) gamma and delta genes from adult, SCID thymocytes reveals coding joints with an increased number of P nucleotides. One-third of P sequences are greater than or equal to 4 nucleotides in length and P elements of up to 15 bases are observed. This suggests that the SCID defect deregulates P nucleotide addition. Consequently, essential V(D)J recombination intermediates may seldom be generated.
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spelling pubmed-21189632008-04-17 T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion J Exp Med Articles The severe combined immunodeficiency (SCID) mutation has been postulated to affect a V(D)J recombinase activity involved in coding joint formation. Analysis of 38 joints from 34 distinct sequences of normally rearranged T cell receptor (TCR) gamma and delta genes from adult, SCID thymocytes reveals coding joints with an increased number of P nucleotides. One-third of P sequences are greater than or equal to 4 nucleotides in length and P elements of up to 15 bases are observed. This suggests that the SCID defect deregulates P nucleotide addition. Consequently, essential V(D)J recombination intermediates may seldom be generated. The Rockefeller University Press 1991-10-01 /pmc/articles/PMC2118963/ /pubmed/1655945 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion
title T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion
title_full T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion
title_fullStr T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion
title_full_unstemmed T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion
title_short T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion
title_sort t cell receptor gamma and delta gene junctional sequences in scid mice: excessive p nucleotide insertion
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118963/
https://www.ncbi.nlm.nih.gov/pubmed/1655945

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