Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes

In mice double transgenic for functionally rearranged T cell receptor (TCR) V beta 2 and V beta 8.2 genes we found that most T lymphocytes express both TCR beta chains simultaneously. These T cells show no abnormality in thymic selection in vivo and their TCRs are capable of transducing activation s...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1991
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118971/
https://www.ncbi.nlm.nih.gov/pubmed/1655946
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collection PubMed
description In mice double transgenic for functionally rearranged T cell receptor (TCR) V beta 2 and V beta 8.2 genes we found that most T lymphocytes express both TCR beta chains simultaneously. These T cells show no abnormality in thymic selection in vivo and their TCRs are capable of transducing activation signals in vitro. These results indicate that multispecific T cells may appear in the periphery if allelic exclusion of TCR beta genes is not established at the level of gene rearrangement.
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spelling pubmed-21189712008-04-17 Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes J Exp Med Articles In mice double transgenic for functionally rearranged T cell receptor (TCR) V beta 2 and V beta 8.2 genes we found that most T lymphocytes express both TCR beta chains simultaneously. These T cells show no abnormality in thymic selection in vivo and their TCRs are capable of transducing activation signals in vitro. These results indicate that multispecific T cells may appear in the periphery if allelic exclusion of TCR beta genes is not established at the level of gene rearrangement. The Rockefeller University Press 1991-10-01 /pmc/articles/PMC2118971/ /pubmed/1655946 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes
title Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes
title_full Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes
title_fullStr Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes
title_full_unstemmed Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes
title_short Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes
title_sort allelic exclusion at dna rearrangement level is required to prevent coexpression of two distinct t cell receptor beta genes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118971/
https://www.ncbi.nlm.nih.gov/pubmed/1655946

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