Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution

We have previously found that a Tyr residue was critical for the interaction of peptides with the Kd molecule, and therefore may be acting as an anchor residue. In the present report we show that it is possible to convert a self peptide sequence into a Kd-restricted neo- antigen by a single Tyr subs...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1991
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119022/
https://www.ncbi.nlm.nih.gov/pubmed/1744590
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description We have previously found that a Tyr residue was critical for the interaction of peptides with the Kd molecule, and therefore may be acting as an anchor residue. In the present report we show that it is possible to convert a self peptide sequence into a Kd-restricted neo- antigen by a single Tyr substitution at position 2 of the peptide. This supports the idea that Tyr is a critical element in the binding motif of Kd-restricted peptides and is a finding that could also prove useful for vaccine development.
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spelling pubmed-21190222008-04-17 Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution J Exp Med Articles We have previously found that a Tyr residue was critical for the interaction of peptides with the Kd molecule, and therefore may be acting as an anchor residue. In the present report we show that it is possible to convert a self peptide sequence into a Kd-restricted neo- antigen by a single Tyr substitution at position 2 of the peptide. This supports the idea that Tyr is a critical element in the binding motif of Kd-restricted peptides and is a finding that could also prove useful for vaccine development. The Rockefeller University Press 1991-12-01 /pmc/articles/PMC2119022/ /pubmed/1744590 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution
title Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution
title_full Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution
title_fullStr Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution
title_full_unstemmed Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution
title_short Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution
title_sort conversion of a self peptide sequence into a kd-restricted neo-antigen by a tyr substitution
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119022/
https://www.ncbi.nlm.nih.gov/pubmed/1744590

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