Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility

A murine monoclonal antibody (M31-15) was identified using the penetration-inhibiting assay of a human lung adenocarcinoma cell line (MAC10) and remarkably inhibited the phagokinetic tract motility of various cancer cell lines. The antigen, motility-related protein (MRP- 1), recognized by M31-15, wa...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1991
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119050/
https://www.ncbi.nlm.nih.gov/pubmed/1720807
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collection PubMed
description A murine monoclonal antibody (M31-15) was identified using the penetration-inhibiting assay of a human lung adenocarcinoma cell line (MAC10) and remarkably inhibited the phagokinetic tract motility of various cancer cell lines. The antigen, motility-related protein (MRP- 1), recognized by M31-15, was 25- and 28-kD proteins, and M31-15 was used to isolate a cDNA clone from a human breast carcinoma cDNA library. Sequence analysis revealed that MRP-1 had strong similarity with a B cell surface antigen (CD37), a melanoma-associated antigen (ME491), the target of an antiproliferative antibody (TAPA-1), a human tumor-associated antigen (CO-029), and the Sm23 antigen of the trematode parasite Schistosoma mansoni.
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spelling pubmed-21190502008-04-17 Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility J Exp Med Articles A murine monoclonal antibody (M31-15) was identified using the penetration-inhibiting assay of a human lung adenocarcinoma cell line (MAC10) and remarkably inhibited the phagokinetic tract motility of various cancer cell lines. The antigen, motility-related protein (MRP- 1), recognized by M31-15, was 25- and 28-kD proteins, and M31-15 was used to isolate a cDNA clone from a human breast carcinoma cDNA library. Sequence analysis revealed that MRP-1 had strong similarity with a B cell surface antigen (CD37), a melanoma-associated antigen (ME491), the target of an antiproliferative antibody (TAPA-1), a human tumor-associated antigen (CO-029), and the Sm23 antigen of the trematode parasite Schistosoma mansoni. The Rockefeller University Press 1991-12-01 /pmc/articles/PMC2119050/ /pubmed/1720807 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility
title Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility
title_full Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility
title_fullStr Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility
title_full_unstemmed Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility
title_short Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility
title_sort identification of the motility-related protein (mrp-1), recognized by monoclonal antibody m31-15, which inhibits cell motility
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119050/
https://www.ncbi.nlm.nih.gov/pubmed/1720807

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