Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue

The present study examined mechanisms of tolerance for T cell receptor gamma/delta (TCR-gamma/delta) cells. Using a transgenic (Tg) model, we demonstrate that although alloantigen (Ag)-specific TCR-gamma/delta cells are deleted in the thymus and spleen of Ag-bearing mice, intraepithelial lymphocytes...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1992
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119083/
https://www.ncbi.nlm.nih.gov/pubmed/1730927
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collection PubMed
description The present study examined mechanisms of tolerance for T cell receptor gamma/delta (TCR-gamma/delta) cells. Using a transgenic (Tg) model, we demonstrate that although alloantigen (Ag)-specific TCR-gamma/delta cells are deleted in the thymus and spleen of Ag-bearing mice, intraepithelial lymphocytes (IELs) expressing normal levels of the Tg TCR were present. However, Tg+ IELs from Ag-bearing mice were unresponsive to activation. Furthermore, self-reactive Tg+ IELs decreased in number over time. Thus, in epithelial tissue, Tg TCR- gamma/delta cells are eliminated subsequent to and most likely as a result of the induction of clonal anergy.
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spelling pubmed-21190832008-04-16 Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue J Exp Med Articles The present study examined mechanisms of tolerance for T cell receptor gamma/delta (TCR-gamma/delta) cells. Using a transgenic (Tg) model, we demonstrate that although alloantigen (Ag)-specific TCR-gamma/delta cells are deleted in the thymus and spleen of Ag-bearing mice, intraepithelial lymphocytes (IELs) expressing normal levels of the Tg TCR were present. However, Tg+ IELs from Ag-bearing mice were unresponsive to activation. Furthermore, self-reactive Tg+ IELs decreased in number over time. Thus, in epithelial tissue, Tg TCR- gamma/delta cells are eliminated subsequent to and most likely as a result of the induction of clonal anergy. The Rockefeller University Press 1992-01-01 /pmc/articles/PMC2119083/ /pubmed/1730927 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue
title Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue
title_full Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue
title_fullStr Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue
title_full_unstemmed Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue
title_short Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue
title_sort mechanism of self-tolerance of gamma/delta t cells in epithelial tissue
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119083/
https://www.ncbi.nlm.nih.gov/pubmed/1730927

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