Assessment of in vivo frequency of mutated T cells in patients with systemic lupus erythematosus

The frequency of mutant T cells (FMC) in blood lymphocytes from patients with systemic lupus erythematosus (SLE) was measured by growing cells in the presence and in the absence of 6-thioguanine. Patients with SLE had a spectrum of FMC ranging from normal to about 100 times normal. This high FMC amo...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1992
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119089/
https://www.ncbi.nlm.nih.gov/pubmed/1730923
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collection PubMed
description The frequency of mutant T cells (FMC) in blood lymphocytes from patients with systemic lupus erythematosus (SLE) was measured by growing cells in the presence and in the absence of 6-thioguanine. Patients with SLE had a spectrum of FMC ranging from normal to about 100 times normal. This high FMC among cells from SLE patients appears to reflect excessive in vivo activation and proliferation during the course of the disease. This represents the first demonstration of such a T cell abnormality in SLE; it supports the hypothesis that SLE T cells demonstrate increased in vivo division and/or survival.
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spelling pubmed-21190892008-04-16 Assessment of in vivo frequency of mutated T cells in patients with systemic lupus erythematosus J Exp Med Articles The frequency of mutant T cells (FMC) in blood lymphocytes from patients with systemic lupus erythematosus (SLE) was measured by growing cells in the presence and in the absence of 6-thioguanine. Patients with SLE had a spectrum of FMC ranging from normal to about 100 times normal. This high FMC among cells from SLE patients appears to reflect excessive in vivo activation and proliferation during the course of the disease. This represents the first demonstration of such a T cell abnormality in SLE; it supports the hypothesis that SLE T cells demonstrate increased in vivo division and/or survival. The Rockefeller University Press 1992-01-01 /pmc/articles/PMC2119089/ /pubmed/1730923 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Assessment of in vivo frequency of mutated T cells in patients with systemic lupus erythematosus
title Assessment of in vivo frequency of mutated T cells in patients with systemic lupus erythematosus
title_full Assessment of in vivo frequency of mutated T cells in patients with systemic lupus erythematosus
title_fullStr Assessment of in vivo frequency of mutated T cells in patients with systemic lupus erythematosus
title_full_unstemmed Assessment of in vivo frequency of mutated T cells in patients with systemic lupus erythematosus
title_short Assessment of in vivo frequency of mutated T cells in patients with systemic lupus erythematosus
title_sort assessment of in vivo frequency of mutated t cells in patients with systemic lupus erythematosus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119089/
https://www.ncbi.nlm.nih.gov/pubmed/1730923

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