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Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements
The immunosuppressant hormone dexamethasone (Dex) interferes with T cell-specific signals activating the enhancer sequences directing interleukin 2 (IL-2) transcription. We report that the Dex-dependent downregulation of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and calcium ionophore-induced activ...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1992
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119143/ https://www.ncbi.nlm.nih.gov/pubmed/1740658 |