A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31)

The molecular nature of cell adhesion mediated by platelet/endothelial cell adhesion molecule 1 (PECAM-1; CD31) was examined using stably transfected L cells in a PECAM-dependent aggregation assay. This adhesion was temperature sensitive and divalent cation dependent, with Mg2+ supporting aggregatio...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1992
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119223/
https://www.ncbi.nlm.nih.gov/pubmed/1569405
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collection PubMed
description The molecular nature of cell adhesion mediated by platelet/endothelial cell adhesion molecule 1 (PECAM-1; CD31) was examined using stably transfected L cells in a PECAM-dependent aggregation assay. This adhesion was temperature sensitive and divalent cation dependent, with Mg2+ supporting aggregation to a greater degree than Ca2+. PECAM- dependent aggregation was heterophilic: PECAM-1 transfectants bound as readily to control-transfected L cells as to other PECAM-1 transfectants, demonstrating that a molecule endogenously expressed on the L cells serves as the ligand for PECAM in this system and presumably substitutes for the natural human ligand.
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spelling pubmed-21192232008-04-16 A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31) J Exp Med Articles The molecular nature of cell adhesion mediated by platelet/endothelial cell adhesion molecule 1 (PECAM-1; CD31) was examined using stably transfected L cells in a PECAM-dependent aggregation assay. This adhesion was temperature sensitive and divalent cation dependent, with Mg2+ supporting aggregation to a greater degree than Ca2+. PECAM- dependent aggregation was heterophilic: PECAM-1 transfectants bound as readily to control-transfected L cells as to other PECAM-1 transfectants, demonstrating that a molecule endogenously expressed on the L cells serves as the ligand for PECAM in this system and presumably substitutes for the natural human ligand. The Rockefeller University Press 1992-05-01 /pmc/articles/PMC2119223/ /pubmed/1569405 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31)
title A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31)
title_full A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31)
title_fullStr A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31)
title_full_unstemmed A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31)
title_short A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31)
title_sort heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (cd31)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119223/
https://www.ncbi.nlm.nih.gov/pubmed/1569405

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