Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells

Thymic epithelial cell lines (TECs) were established from newborn C57BL/6 mice. They were classified into two types (medullary and cortical TECs) by using the monoclonal antibody (Th-3) that recognizes the meshwork structure of thymic cortical epithelial cells. Antigen- presenting activity of each T...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1992
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119245/
https://www.ncbi.nlm.nih.gov/pubmed/1534114
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description Thymic epithelial cell lines (TECs) were established from newborn C57BL/6 mice. They were classified into two types (medullary and cortical TECs) by using the monoclonal antibody (Th-3) that recognizes the meshwork structure of thymic cortical epithelial cells. Antigen- presenting activity of each TEC was determined by using ovalbumin- specific, I-Ab-restricted helper T cell lines. It was demonstrated that the medullary but not the cortical TECs functioned as antigen- presenting cells. This is the first evidence for the functional difference between the cortical and the medullary TEC.
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spelling pubmed-21192452008-04-16 Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells J Exp Med Articles Thymic epithelial cell lines (TECs) were established from newborn C57BL/6 mice. They were classified into two types (medullary and cortical TECs) by using the monoclonal antibody (Th-3) that recognizes the meshwork structure of thymic cortical epithelial cells. Antigen- presenting activity of each TEC was determined by using ovalbumin- specific, I-Ab-restricted helper T cell lines. It was demonstrated that the medullary but not the cortical TECs functioned as antigen- presenting cells. This is the first evidence for the functional difference between the cortical and the medullary TEC. The Rockefeller University Press 1992-06-01 /pmc/articles/PMC2119245/ /pubmed/1534114 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells
title Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells
title_full Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells
title_fullStr Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells
title_full_unstemmed Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells
title_short Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells
title_sort medullary but not cortical thymic epithelial cells present soluble antigens to helper t cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119245/
https://www.ncbi.nlm.nih.gov/pubmed/1534114

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