The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex

A previously unknown major histocompatibility complex class II molecule consisting of the beta chain encoded by the H-2Ob gene and an unknown alpha chain was recently described. We now report that the alpha chain occurs in two allelic forms distinguished by charge difference. Using inbred recombinan...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1992
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119318/
https://www.ncbi.nlm.nih.gov/pubmed/1354242
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collection PubMed
description A previously unknown major histocompatibility complex class II molecule consisting of the beta chain encoded by the H-2Ob gene and an unknown alpha chain was recently described. We now report that the alpha chain occurs in two allelic forms distinguished by charge difference. Using inbred recombinant mouse strains we were able to map the H-2Oa gene to a location between the A.TL and B10.MBR recombination points. Cosmids covering this region were used to isolate the gene. Sequence analysis revealed that the H-2Oa gene is the murine equivalent of the human HLA- DNA gene. These results indicate that the human HLA-DNA gene, the existence of which has long been known, is indeed coding for DO alpha, the alpha chain pairing with DO beta.
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spelling pubmed-21193182008-04-16 The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex J Exp Med Articles A previously unknown major histocompatibility complex class II molecule consisting of the beta chain encoded by the H-2Ob gene and an unknown alpha chain was recently described. We now report that the alpha chain occurs in two allelic forms distinguished by charge difference. Using inbred recombinant mouse strains we were able to map the H-2Oa gene to a location between the A.TL and B10.MBR recombination points. Cosmids covering this region were used to isolate the gene. Sequence analysis revealed that the H-2Oa gene is the murine equivalent of the human HLA- DNA gene. These results indicate that the human HLA-DNA gene, the existence of which has long been known, is indeed coding for DO alpha, the alpha chain pairing with DO beta. The Rockefeller University Press 1992-08-01 /pmc/articles/PMC2119318/ /pubmed/1354242 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex
title The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex
title_full The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex
title_fullStr The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex
title_full_unstemmed The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex
title_short The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex
title_sort alpha chain gene of h-2o has an unexpected location in the major histocompatibility complex
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119318/
https://www.ncbi.nlm.nih.gov/pubmed/1354242

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