Protection in simian immunodeficiency virus-vaccinated monkeys correlates with anti-HLA class I antibody response

Our earlier reports demonstrated that Cynomolgus macaques vaccinated with either inactivated partially purified simian immunodeficiency virus (SIV), fixed SIV-infected C8166 (a human T lymphoblastoid cell line) cells, or fixed uninfected C8166 cells can be protected against a challenge infection wit...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1992
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119400/
https://www.ncbi.nlm.nih.gov/pubmed/1402662
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collection PubMed
description Our earlier reports demonstrated that Cynomolgus macaques vaccinated with either inactivated partially purified simian immunodeficiency virus (SIV), fixed SIV-infected C8166 (a human T lymphoblastoid cell line) cells, or fixed uninfected C8166 cells can be protected against a challenge infection with the 32H isolate of SIVmac 251 (grown in C8166) (Stott, E. J., W. L. Chan, K. H. G. Mills, M. Page, F. Taffs, M. Cranage, P. Greenway, and P. Kitchin. 1990. Lancet. 336:1538; Stott, E. J., P. A. Kitchin, M. Page, B. Flanagan, L. F. Taffs, W. L. Chan, K. H. G. Mills, P. Silvera, and A. Rodgers. 1991. Nature [Lond.]. 353:393). Protection is correlated with the levels of antibody response to cellular antigens in the human cells from which the virus immunogen was grown. However, the mechanism of protection is unclear. We report here the analysis of sera from these protected monkeys and demonstrate that there is positive correlation of protection with antibody response to the HLA class I molecule.
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spelling pubmed-21194002008-04-16 Protection in simian immunodeficiency virus-vaccinated monkeys correlates with anti-HLA class I antibody response J Exp Med Articles Our earlier reports demonstrated that Cynomolgus macaques vaccinated with either inactivated partially purified simian immunodeficiency virus (SIV), fixed SIV-infected C8166 (a human T lymphoblastoid cell line) cells, or fixed uninfected C8166 cells can be protected against a challenge infection with the 32H isolate of SIVmac 251 (grown in C8166) (Stott, E. J., W. L. Chan, K. H. G. Mills, M. Page, F. Taffs, M. Cranage, P. Greenway, and P. Kitchin. 1990. Lancet. 336:1538; Stott, E. J., P. A. Kitchin, M. Page, B. Flanagan, L. F. Taffs, W. L. Chan, K. H. G. Mills, P. Silvera, and A. Rodgers. 1991. Nature [Lond.]. 353:393). Protection is correlated with the levels of antibody response to cellular antigens in the human cells from which the virus immunogen was grown. However, the mechanism of protection is unclear. We report here the analysis of sera from these protected monkeys and demonstrate that there is positive correlation of protection with antibody response to the HLA class I molecule. The Rockefeller University Press 1992-10-01 /pmc/articles/PMC2119400/ /pubmed/1402662 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Protection in simian immunodeficiency virus-vaccinated monkeys correlates with anti-HLA class I antibody response
title Protection in simian immunodeficiency virus-vaccinated monkeys correlates with anti-HLA class I antibody response
title_full Protection in simian immunodeficiency virus-vaccinated monkeys correlates with anti-HLA class I antibody response
title_fullStr Protection in simian immunodeficiency virus-vaccinated monkeys correlates with anti-HLA class I antibody response
title_full_unstemmed Protection in simian immunodeficiency virus-vaccinated monkeys correlates with anti-HLA class I antibody response
title_short Protection in simian immunodeficiency virus-vaccinated monkeys correlates with anti-HLA class I antibody response
title_sort protection in simian immunodeficiency virus-vaccinated monkeys correlates with anti-hla class i antibody response
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119400/
https://www.ncbi.nlm.nih.gov/pubmed/1402662

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