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Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci
In MRL mice, the mostly recessive lpr mutation results in both the accumulation of CD4-, CD8-, CD3+ T cells in lymphoid tissue and many features of generalized autoimmune disease, including immune complex glomerulonephritis. To positionally clone the lpr mutation and analyze the effects of backgroun...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1992
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119463/ https://www.ncbi.nlm.nih.gov/pubmed/1460423 |