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SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway
SPARC (osteonectin/BM40) is a secreted protein that modifies the interaction of cells with extracellular matrix (ECM). When we added SPARC to cultured rabbit synovial fibroblasts and analyzed the secreted proteins, we observed an increase in the expression of three metalloproteinases--collagenase, s...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1993
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119706/ https://www.ncbi.nlm.nih.gov/pubmed/8509459 |