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Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor

Catenins mediate the linkage of classical cadherins with actin microfilaments and are part of a higher order protein structure by which cadherins are connected to other cytoplasmic and transmembrane proteins. The ratio of actin-bound to free cadherin-catenin complex, which varies depending on the ty...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2120252/
https://www.ncbi.nlm.nih.gov/pubmed/7962096
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collection PubMed
description Catenins mediate the linkage of classical cadherins with actin microfilaments and are part of a higher order protein structure by which cadherins are connected to other cytoplasmic and transmembrane proteins. The ratio of actin-bound to free cadherin-catenin complex, which varies depending on the type and growth rate of cells, is thought to be altered by cellular signals, such as those associated with mitosis, polarization of cells and growth factors during development. EGF induces an immediate tyrosine phosphorylation of beta-catenin and gamma-catenin (plakoglobin). We show here an association of the EGF- receptor with the cadherin-catenin complex. Using recombinant proteins we demonstrate the interaction of EGF-receptor and beta-catenin in in vitro kinase assays. This interaction is mediated by the evolutionarily conserved central "core" region of beta-catenin. These results suggest that catenins represent an important link between EGF-induced signal transduction and cadherin function.
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spelling pubmed-21202522008-05-01 Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor J Cell Biol Articles Catenins mediate the linkage of classical cadherins with actin microfilaments and are part of a higher order protein structure by which cadherins are connected to other cytoplasmic and transmembrane proteins. The ratio of actin-bound to free cadherin-catenin complex, which varies depending on the type and growth rate of cells, is thought to be altered by cellular signals, such as those associated with mitosis, polarization of cells and growth factors during development. EGF induces an immediate tyrosine phosphorylation of beta-catenin and gamma-catenin (plakoglobin). We show here an association of the EGF- receptor with the cadherin-catenin complex. Using recombinant proteins we demonstrate the interaction of EGF-receptor and beta-catenin in in vitro kinase assays. This interaction is mediated by the evolutionarily conserved central "core" region of beta-catenin. These results suggest that catenins represent an important link between EGF-induced signal transduction and cadherin function. The Rockefeller University Press 1994-12-01 /pmc/articles/PMC2120252/ /pubmed/7962096 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
title Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
title_full Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
title_fullStr Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
title_full_unstemmed Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
title_short Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
title_sort beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2120252/
https://www.ncbi.nlm.nih.gov/pubmed/7962096