A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium

Analysis of a developmental mutant in Dictyostelium discoideum which is unable to initiate morphogenesis has shown that a protein kinase of the MAP kinase/ERK family affects relay of the cAMP chemotactic signal and cell differentiation. Strains in which the locus encoding ERK2 is disrupted respond t...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1995
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2120359/
https://www.ncbi.nlm.nih.gov/pubmed/7844154
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collection PubMed
description Analysis of a developmental mutant in Dictyostelium discoideum which is unable to initiate morphogenesis has shown that a protein kinase of the MAP kinase/ERK family affects relay of the cAMP chemotactic signal and cell differentiation. Strains in which the locus encoding ERK2 is disrupted respond to a pulse of cAMP by synthesizing cGMP normally but show little synthesis of cAMP. Since mutant cells lacking ERK2 contain normal levels of both the cytosolic regulator of adenylyl cyclase (CRAC) and manganese-activatable adenylyl cyclase, it appears that this kinase is important for receptor-mediated activation of adenylyl cyclase.
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spelling pubmed-21203592008-05-01 A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium J Cell Biol Articles Analysis of a developmental mutant in Dictyostelium discoideum which is unable to initiate morphogenesis has shown that a protein kinase of the MAP kinase/ERK family affects relay of the cAMP chemotactic signal and cell differentiation. Strains in which the locus encoding ERK2 is disrupted respond to a pulse of cAMP by synthesizing cGMP normally but show little synthesis of cAMP. Since mutant cells lacking ERK2 contain normal levels of both the cytosolic regulator of adenylyl cyclase (CRAC) and manganese-activatable adenylyl cyclase, it appears that this kinase is important for receptor-mediated activation of adenylyl cyclase. The Rockefeller University Press 1995-02-01 /pmc/articles/PMC2120359/ /pubmed/7844154 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium
title A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium
title_full A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium
title_fullStr A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium
title_full_unstemmed A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium
title_short A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium
title_sort map kinase necessary for receptor-mediated activation of adenylyl cyclase in dictyostelium
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2120359/
https://www.ncbi.nlm.nih.gov/pubmed/7844154

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