An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes

In this paper, we show that beta COP is present on endosomes and is required for the formation of vesicles which mediate transport from early to late endosomes. Both the association of beta COP to endosomal membranes as well as transport vesicle formation depend on the lumenal pH. We find that epsil...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1996
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2120778/
https://www.ncbi.nlm.nih.gov/pubmed/8601610
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collection PubMed
description In this paper, we show that beta COP is present on endosomes and is required for the formation of vesicles which mediate transport from early to late endosomes. Both the association of beta COP to endosomal membranes as well as transport vesicle formation depend on the lumenal pH. We find that epsilon COP, but not gamma COP, is also associated to endosomes, and that this association is also lumenal pH dependent. Our data, thus, indicate that a subset of COPs is part of the mechanism regulating endosomal membrane transport, and that membrane association of these COPs is controlled by the acidic properties of early endosomes, presumably via a trans-membrane pH sensor.
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spelling pubmed-21207782008-05-01 An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes J Cell Biol Articles In this paper, we show that beta COP is present on endosomes and is required for the formation of vesicles which mediate transport from early to late endosomes. Both the association of beta COP to endosomal membranes as well as transport vesicle formation depend on the lumenal pH. We find that epsilon COP, but not gamma COP, is also associated to endosomes, and that this association is also lumenal pH dependent. Our data, thus, indicate that a subset of COPs is part of the mechanism regulating endosomal membrane transport, and that membrane association of these COPs is controlled by the acidic properties of early endosomes, presumably via a trans-membrane pH sensor. The Rockefeller University Press 1996-04-01 /pmc/articles/PMC2120778/ /pubmed/8601610 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes
title An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes
title_full An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes
title_fullStr An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes
title_full_unstemmed An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes
title_short An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes
title_sort endosomal beta cop is involved in the ph-dependent formation of transport vesicles destined for late endosomes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2120778/
https://www.ncbi.nlm.nih.gov/pubmed/8601610

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