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Dosage Compensation in the Mouse Balances Up-Regulation and Silencing of X-Linked Genes

Dosage compensation in mammals involves silencing of one X chromosome in XX females and requires expression, in cis, of Xist RNA. The X to be inactivated is randomly chosen in cells of the inner cell mass (ICM) at the blastocyst stage of development. Embryonic stem (ES) cells derived from the ICM of...

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Detalles Bibliográficos
Autores principales:	Lin, Hong, Gupta, Vibhor, VerMilyea, Matthew D, Falciani, Francesco, Lee, Jeannie T, O'Neill, Laura P, Turner, Bryan M
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2121114/ https://www.ncbi.nlm.nih.gov/pubmed/18076287 http://dx.doi.org/10.1371/journal.pbio.0050326

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