Cargando…
The coregulator Alien
Alien has characteristics of a corepressor for selected members of the nuclear hormone receptor (NHR) superfamily and also for transcription factors involved in cell cycle regulation and DNA repair. Alien mediates gene silencing and represses the transactivation of specific NHRs and other transcript...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Nuclear Receptor Signaling Atlas
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2121318/ https://www.ncbi.nlm.nih.gov/pubmed/18174916 http://dx.doi.org/10.1621/nrs.05008 |
_version_ | 1782141667730522112 |
---|---|
author | Papaioannou, Maria Melle, Christian Baniahmad, Aria |
author_facet | Papaioannou, Maria Melle, Christian Baniahmad, Aria |
author_sort | Papaioannou, Maria |
collection | PubMed |
description | Alien has characteristics of a corepressor for selected members of the nuclear hormone receptor (NHR) superfamily and also for transcription factors involved in cell cycle regulation and DNA repair. Alien mediates gene silencing and represses the transactivation of specific NHRs and other transcription factors to modulate hormone response and cell proliferation. Alien is a highly conserved protein and is expressed in a wide variety of tissues. Knockout of the gene encoding Alien in mice is embryonic lethal at a very early stage, indicating an important evolutionary role in multicellular organisms. From a mechanistic perspective, the corepressor function of Alien is in part mediated by histone deacetylase (HDAC) activity. In addition, Alien seems to modulate nucleosome assembly activity. This suggests that Alien is acting on chromatin not only through recruitment of histone-modifying activities, but also through enhancing nucleosome assembly. |
format | Text |
id | pubmed-2121318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | The Nuclear Receptor Signaling Atlas |
record_format | MEDLINE/PubMed |
spelling | pubmed-21213182007-12-10 The coregulator Alien Papaioannou, Maria Melle, Christian Baniahmad, Aria Nucl Recept Signal Review Alien has characteristics of a corepressor for selected members of the nuclear hormone receptor (NHR) superfamily and also for transcription factors involved in cell cycle regulation and DNA repair. Alien mediates gene silencing and represses the transactivation of specific NHRs and other transcription factors to modulate hormone response and cell proliferation. Alien is a highly conserved protein and is expressed in a wide variety of tissues. Knockout of the gene encoding Alien in mice is embryonic lethal at a very early stage, indicating an important evolutionary role in multicellular organisms. From a mechanistic perspective, the corepressor function of Alien is in part mediated by histone deacetylase (HDAC) activity. In addition, Alien seems to modulate nucleosome assembly activity. This suggests that Alien is acting on chromatin not only through recruitment of histone-modifying activities, but also through enhancing nucleosome assembly. The Nuclear Receptor Signaling Atlas 2007-11-30 /pmc/articles/PMC2121318/ /pubmed/18174916 http://dx.doi.org/10.1621/nrs.05008 Text en Copyright © 2007, Papaioannou et al. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Papaioannou, Maria Melle, Christian Baniahmad, Aria The coregulator Alien |
title | The coregulator Alien
|
title_full | The coregulator Alien
|
title_fullStr | The coregulator Alien
|
title_full_unstemmed | The coregulator Alien
|
title_short | The coregulator Alien
|
title_sort | coregulator alien |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2121318/ https://www.ncbi.nlm.nih.gov/pubmed/18174916 http://dx.doi.org/10.1621/nrs.05008 |
work_keys_str_mv | AT papaioannoumaria thecoregulatoralien AT mellechristian thecoregulatoralien AT baniahmadaria thecoregulatoralien AT papaioannoumaria coregulatoralien AT mellechristian coregulatoralien AT baniahmadaria coregulatoralien |