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THE RELATION OF PROTEIN, LIPOIDS AND SALTS TO THE WASSERMANN REACTION

1. The high value in respect to complement-binding exhibited by blood sera from syphilitics and spinal fluids from general paralytics is associated with an excessively high content of globulin, but there does not exist a direct quantitative relation between the two. Cases of secondary syphilis which...

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Autor principal: Noguchi, Hideyo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1909
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2124696/
https://www.ncbi.nlm.nih.gov/pubmed/19867245
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author Noguchi, Hideyo
author_facet Noguchi, Hideyo
author_sort Noguchi, Hideyo
collection PubMed
description 1. The high value in respect to complement-binding exhibited by blood sera from syphilitics and spinal fluids from general paralytics is associated with an excessively high content of globulin, but there does not exist a direct quantitative relation between the two. Cases of secondary syphilis which have been under prolonged and proper medication do not exhibit the globulin increase and usually fail to give the Wassermann reaction. The active substances entering into the Wassermann reaction are precipitable with the globulin and chiefly with the euglobulin fraction of the fluids. 2. Temperatures of 70° to 76° C. destroy the active substances. Exposed to sunlight the active substances deteriorate slowly. A photodynamic substance such as eosin, under the direct influence of the sun, brings about their complete and rapid destruction. This effect does not occur in the dark. The active substances are subject to tryptic and peptic digestion and are destroyed by weak acids and alkalies. 3. The active substances in the blood sera and spinal fluids cannot be separated from them or from the globulin precipitate by alcohol. 4. There are contained in the alcoholic extracts of normal and syphilitic blood and organs certain acetone-soluble lipoids which possess high antigenic values for the Wasserman reaction. Cholesterin is inactive and the bile salts less active than the lipoidal bodies. 5. Sodium cholate is about as active as sodium taurocholate and glycocholate, but neurin and cholin are inactive.
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spelling pubmed-21246962008-04-18 THE RELATION OF PROTEIN, LIPOIDS AND SALTS TO THE WASSERMANN REACTION Noguchi, Hideyo J Exp Med Article 1. The high value in respect to complement-binding exhibited by blood sera from syphilitics and spinal fluids from general paralytics is associated with an excessively high content of globulin, but there does not exist a direct quantitative relation between the two. Cases of secondary syphilis which have been under prolonged and proper medication do not exhibit the globulin increase and usually fail to give the Wassermann reaction. The active substances entering into the Wassermann reaction are precipitable with the globulin and chiefly with the euglobulin fraction of the fluids. 2. Temperatures of 70° to 76° C. destroy the active substances. Exposed to sunlight the active substances deteriorate slowly. A photodynamic substance such as eosin, under the direct influence of the sun, brings about their complete and rapid destruction. This effect does not occur in the dark. The active substances are subject to tryptic and peptic digestion and are destroyed by weak acids and alkalies. 3. The active substances in the blood sera and spinal fluids cannot be separated from them or from the globulin precipitate by alcohol. 4. There are contained in the alcoholic extracts of normal and syphilitic blood and organs certain acetone-soluble lipoids which possess high antigenic values for the Wasserman reaction. Cholesterin is inactive and the bile salts less active than the lipoidal bodies. 5. Sodium cholate is about as active as sodium taurocholate and glycocholate, but neurin and cholin are inactive. The Rockefeller University Press 1909-01-09 /pmc/articles/PMC2124696/ /pubmed/19867245 Text en Copyright © Copyright, 1909, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Noguchi, Hideyo
THE RELATION OF PROTEIN, LIPOIDS AND SALTS TO THE WASSERMANN REACTION
title THE RELATION OF PROTEIN, LIPOIDS AND SALTS TO THE WASSERMANN REACTION
title_full THE RELATION OF PROTEIN, LIPOIDS AND SALTS TO THE WASSERMANN REACTION
title_fullStr THE RELATION OF PROTEIN, LIPOIDS AND SALTS TO THE WASSERMANN REACTION
title_full_unstemmed THE RELATION OF PROTEIN, LIPOIDS AND SALTS TO THE WASSERMANN REACTION
title_short THE RELATION OF PROTEIN, LIPOIDS AND SALTS TO THE WASSERMANN REACTION
title_sort relation of protein, lipoids and salts to the wassermann reaction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2124696/
https://www.ncbi.nlm.nih.gov/pubmed/19867245
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