THE INFLUENCE OF ADRENALIN IN PHLORHIZIN DIABETES

I. Intraperitoneal injections of adrenalin into animals which are completely under the influence of phlorhizin and which are free from glycogen do not result in any extra elimination of sugar. This proves that adrenalin does not cause a conversion of fat into carbohydrates, as is maintained by Blum and by Eppinger, Falta and Rudinger. II. The high D:N ratio 5.2 and 6.1 reported by Eppinger, Falta and Rudinger after adrenalin injections in depancreatized dogs, which were obtained after short periods of six hours and four hours respectively, can be explained by the elimination of carbohydrates present in the organism. III. These results confirm the work of Straub and Ritzmann which indicates that adrenalin, by its constricting effect on the blood vessels, produces anemia of the tissues, resulting in imperfect oxidation, and this anemia is followed by the conversion of glycogen into dextrose by hyperglycemia and consequently by glycosuria.