THE RATE OF REGENERATION OF BLOOD PLATELETS

By repeatedly withdrawing, defibrinating, and reinjecting blood, the platelet count in dogs can be reduced to an extremely low level. When the reduction in platelets and fibrinogen has been carried to an extreme degree the animals display a marked tendency to bleed. The regeneration of platelets aft...

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Detalles Bibliográficos
Autor principal: Duke, W. W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1911
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2124774/
https://www.ncbi.nlm.nih.gov/pubmed/19867471
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author Duke, W. W.
author_facet Duke, W. W.
author_sort Duke, W. W.
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description By repeatedly withdrawing, defibrinating, and reinjecting blood, the platelet count in dogs can be reduced to an extremely low level. When the reduction in platelets and fibrinogen has been carried to an extreme degree the animals display a marked tendency to bleed. The regeneration of platelets after their removal by defibrination is remarkably rapid and amounts, on an average, to about one fifth of the entire number in the blood per day. From the experiments and from observations on the platelet count in human beings, it is believed that under the usual conditions of life platelets are utilized or destroyed and replaced in enormous numbers daily, and that the life cycle of the platelet is extremely short,—possibly a matter of a few days.
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spelling pubmed-21247742008-04-18 THE RATE OF REGENERATION OF BLOOD PLATELETS Duke, W. W. J Exp Med Article By repeatedly withdrawing, defibrinating, and reinjecting blood, the platelet count in dogs can be reduced to an extremely low level. When the reduction in platelets and fibrinogen has been carried to an extreme degree the animals display a marked tendency to bleed. The regeneration of platelets after their removal by defibrination is remarkably rapid and amounts, on an average, to about one fifth of the entire number in the blood per day. From the experiments and from observations on the platelet count in human beings, it is believed that under the usual conditions of life platelets are utilized or destroyed and replaced in enormous numbers daily, and that the life cycle of the platelet is extremely short,—possibly a matter of a few days. The Rockefeller University Press 1911-09-01 /pmc/articles/PMC2124774/ /pubmed/19867471 Text en Copyright © Copyright, 1911, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Duke, W. W.
THE RATE OF REGENERATION OF BLOOD PLATELETS
title THE RATE OF REGENERATION OF BLOOD PLATELETS
title_full THE RATE OF REGENERATION OF BLOOD PLATELETS
title_fullStr THE RATE OF REGENERATION OF BLOOD PLATELETS
title_full_unstemmed THE RATE OF REGENERATION OF BLOOD PLATELETS
title_short THE RATE OF REGENERATION OF BLOOD PLATELETS
title_sort rate of regeneration of blood platelets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2124774/
https://www.ncbi.nlm.nih.gov/pubmed/19867471
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