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A TRANSMISSIBLE AVIAN NEOPLASM. (SARCOMA OF THE COMMON FOWL.)
In this paper is reported the first avian tumor that has proved transplantable to other individuals. It is a spindle-celled sarcoma of the hen, which thus far has been propagated into its fourth tumor generation. This was accomplished by the use of fowls of pure blood from the small, intimately rela...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1910
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2124810/ https://www.ncbi.nlm.nih.gov/pubmed/19867354 |
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author | Rous, Peyton |
author_facet | Rous, Peyton |
author_sort | Rous, Peyton |
collection | PubMed |
description | In this paper is reported the first avian tumor that has proved transplantable to other individuals. It is a spindle-celled sarcoma of the hen, which thus far has been propagated into its fourth tumor generation. This was accomplished by the use of fowls of pure blood from the small, intimately related stock in which the growth occurred. Market-bought fowls of similar variety have shown themselves insusceptible, as have fowls of mixed breed, pigeons and guinea-pigs. The percentage of successful transplantations has been small, but in the individuals developing a tumor its growth has been fairly rapid. Young chickens are more susceptible than adults. The reinoculation of negative fowls has never resulted in a growth. Throughout, the sarcoma has remained true to type. It is infiltrative and destructive. Metastasis has been observed once (to the heart). Experiments to determine whether the growth may be transmitted by cell-fragments have not yet been made. Repeated bacteriological examinations have yielded negative results. In its general behavior, so far as tested, this avian tumor closely resembles the typical mammalian neoplasms that are transplantable. |
format | Text |
id | pubmed-2124810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1910 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21248102008-04-18 A TRANSMISSIBLE AVIAN NEOPLASM. (SARCOMA OF THE COMMON FOWL.) Rous, Peyton J Exp Med Article In this paper is reported the first avian tumor that has proved transplantable to other individuals. It is a spindle-celled sarcoma of the hen, which thus far has been propagated into its fourth tumor generation. This was accomplished by the use of fowls of pure blood from the small, intimately related stock in which the growth occurred. Market-bought fowls of similar variety have shown themselves insusceptible, as have fowls of mixed breed, pigeons and guinea-pigs. The percentage of successful transplantations has been small, but in the individuals developing a tumor its growth has been fairly rapid. Young chickens are more susceptible than adults. The reinoculation of negative fowls has never resulted in a growth. Throughout, the sarcoma has remained true to type. It is infiltrative and destructive. Metastasis has been observed once (to the heart). Experiments to determine whether the growth may be transmitted by cell-fragments have not yet been made. Repeated bacteriological examinations have yielded negative results. In its general behavior, so far as tested, this avian tumor closely resembles the typical mammalian neoplasms that are transplantable. The Rockefeller University Press 1910-09-01 /pmc/articles/PMC2124810/ /pubmed/19867354 Text en Copyright © Copyright, 1910, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Rous, Peyton A TRANSMISSIBLE AVIAN NEOPLASM. (SARCOMA OF THE COMMON FOWL.) |
title | A TRANSMISSIBLE AVIAN NEOPLASM. (SARCOMA OF THE COMMON FOWL.) |
title_full | A TRANSMISSIBLE AVIAN NEOPLASM. (SARCOMA OF THE COMMON FOWL.) |
title_fullStr | A TRANSMISSIBLE AVIAN NEOPLASM. (SARCOMA OF THE COMMON FOWL.) |
title_full_unstemmed | A TRANSMISSIBLE AVIAN NEOPLASM. (SARCOMA OF THE COMMON FOWL.) |
title_short | A TRANSMISSIBLE AVIAN NEOPLASM. (SARCOMA OF THE COMMON FOWL.) |
title_sort | transmissible avian neoplasm. (sarcoma of the common fowl.) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2124810/ https://www.ncbi.nlm.nih.gov/pubmed/19867354 |
work_keys_str_mv | AT rouspeyton atransmissibleavianneoplasmsarcomaofthecommonfowl AT rouspeyton transmissibleavianneoplasmsarcomaofthecommonfowl |