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THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS

Subdural inoculation of tubercle bacilli of established virulence for guinea pigs and rabbits, produces in the dog a tuberculous meningitis, followed by paralysis and death. When suspensions of canine leucocytes are injected subdurally, following such inoculations there occurs uniformly a delay in t...

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Detalles Bibliográficos
Autor principal: Manwaring, Wilfred H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1912
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2124941/
https://www.ncbi.nlm.nih.gov/pubmed/19867502
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author Manwaring, Wilfred H.
author_facet Manwaring, Wilfred H.
author_sort Manwaring, Wilfred H.
collection PubMed
description Subdural inoculation of tubercle bacilli of established virulence for guinea pigs and rabbits, produces in the dog a tuberculous meningitis, followed by paralysis and death. When suspensions of canine leucocytes are injected subdurally, following such inoculations there occurs uniformly a delay in the development of the paralysis and a prolongation of the life of the treated animal. In dogs inoculated with small doses of tubercle bacilli of low virulence, the development of paralysis has been prevented by this means for periods of seven months (up to the present date), while the untreated animals injected with the same cultures have all developed paralytic symptoms within a period of about four weeks.
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spelling pubmed-21249412008-04-18 THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS Manwaring, Wilfred H. J Exp Med Article Subdural inoculation of tubercle bacilli of established virulence for guinea pigs and rabbits, produces in the dog a tuberculous meningitis, followed by paralysis and death. When suspensions of canine leucocytes are injected subdurally, following such inoculations there occurs uniformly a delay in the development of the paralysis and a prolongation of the life of the treated animal. In dogs inoculated with small doses of tubercle bacilli of low virulence, the development of paralysis has been prevented by this means for periods of seven months (up to the present date), while the untreated animals injected with the same cultures have all developed paralytic symptoms within a period of about four weeks. The Rockefeller University Press 1912-01-01 /pmc/articles/PMC2124941/ /pubmed/19867502 Text en Copyright © Copyright, 1912, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Manwaring, Wilfred H.
THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
title THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
title_full THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
title_fullStr THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
title_full_unstemmed THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
title_short THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
title_sort effects of subdural injections of leucocytes on the development and course of experimental tuberculous meningitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2124941/
https://www.ncbi.nlm.nih.gov/pubmed/19867502
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