Cargando…

CONDITIONS GOVERNING THE GROWTH OF DISPLACED NORMAL TISSUE

We are unwilling to draw any very definite conclusions from the experiments, partly because they show a survival of implanted skin of so much shorter duration than that which seems to occur in the case of spontaneous implantation cysts, and partly because the method of reëxposing the submerged graft...

Descripción completa

Detalles Bibliográficos
Autor principal: Craster, C. V.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1912
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2124984/
https://www.ncbi.nlm.nih.gov/pubmed/19867590
_version_ 1782141790549180416
author Craster, C. V.
author_facet Craster, C. V.
author_sort Craster, C. V.
collection PubMed
description We are unwilling to draw any very definite conclusions from the experiments, partly because they show a survival of implanted skin of so much shorter duration than that which seems to occur in the case of spontaneous implantation cysts, and partly because the method of reëxposing the submerged grafts is rather a crude way of testing their vitality. Nevertheless, the following points seem clear: 1. The repeated transplantation of a piece of skin from one animal to another confers no exceptional power of growth upon that skin. 2. The repeated implantation of skin into one animal decreases, if anything, its receptivity for such grafts. 3. The burial of skin in the interior of the body causes, after a time, a change in the skin of such a nature that it cannot resume its normal function as an external covering tissue, even when its circulation \ is well maintained and it is buried in the body of the same animal. The experiments do not determine how long the cells of the skin actually remain alive, and indeed it is conceivable that the mere maceration of the protective horny layer puts the skin, when reëxposed, into the position of a moist tissue, such as the intestinal mucosa, so that it readily dries up and succumbs. Nor do the experiments throw any light upon the possible existence of cytolytic substances in the circulating fluids, although, naturally, the idea of such an action has always been present in our minds in observing the gradual loss of vitality in the transplanted tissues.
format Text
id pubmed-2124984
institution National Center for Biotechnology Information
language English
publishDate 1912
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21249842008-04-18 CONDITIONS GOVERNING THE GROWTH OF DISPLACED NORMAL TISSUE Craster, C. V. J Exp Med Article We are unwilling to draw any very definite conclusions from the experiments, partly because they show a survival of implanted skin of so much shorter duration than that which seems to occur in the case of spontaneous implantation cysts, and partly because the method of reëxposing the submerged grafts is rather a crude way of testing their vitality. Nevertheless, the following points seem clear: 1. The repeated transplantation of a piece of skin from one animal to another confers no exceptional power of growth upon that skin. 2. The repeated implantation of skin into one animal decreases, if anything, its receptivity for such grafts. 3. The burial of skin in the interior of the body causes, after a time, a change in the skin of such a nature that it cannot resume its normal function as an external covering tissue, even when its circulation \ is well maintained and it is buried in the body of the same animal. The experiments do not determine how long the cells of the skin actually remain alive, and indeed it is conceivable that the mere maceration of the protective horny layer puts the skin, when reëxposed, into the position of a moist tissue, such as the intestinal mucosa, so that it readily dries up and succumbs. Nor do the experiments throw any light upon the possible existence of cytolytic substances in the circulating fluids, although, naturally, the idea of such an action has always been present in our minds in observing the gradual loss of vitality in the transplanted tissues. The Rockefeller University Press 1912-10-01 /pmc/articles/PMC2124984/ /pubmed/19867590 Text en Copyright © Copyright, 1912, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Craster, C. V.
CONDITIONS GOVERNING THE GROWTH OF DISPLACED NORMAL TISSUE
title CONDITIONS GOVERNING THE GROWTH OF DISPLACED NORMAL TISSUE
title_full CONDITIONS GOVERNING THE GROWTH OF DISPLACED NORMAL TISSUE
title_fullStr CONDITIONS GOVERNING THE GROWTH OF DISPLACED NORMAL TISSUE
title_full_unstemmed CONDITIONS GOVERNING THE GROWTH OF DISPLACED NORMAL TISSUE
title_short CONDITIONS GOVERNING THE GROWTH OF DISPLACED NORMAL TISSUE
title_sort conditions governing the growth of displaced normal tissue
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2124984/
https://www.ncbi.nlm.nih.gov/pubmed/19867590
work_keys_str_mv AT crastercv conditionsgoverningthegrowthofdisplacednormaltissue