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THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS

Rabbit leucocytes, injected into the basal meninges of dogs, in doses from 0.7 to one cubic centimeter apparently invariably cause death. Horse leucocytes, injected in the same amounts, cause death in about 25 per cent. of the dogs. . The injection of foreign leucocytes into the meninges of monkeys...

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Autor principal: Manwaring, Wilfred H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1913
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125020/
https://www.ncbi.nlm.nih.gov/pubmed/19867619
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author Manwaring, Wilfred H.
author_facet Manwaring, Wilfred H.
author_sort Manwaring, Wilfred H.
collection PubMed
description Rabbit leucocytes, injected into the basal meninges of dogs, in doses from 0.7 to one cubic centimeter apparently invariably cause death. Horse leucocytes, injected in the same amounts, cause death in about 25 per cent. of the dogs. . The injection of foreign leucocytes into the meninges of monkeys causes few if any symptoms. The injection of from one to three cubic centimeters of horse leucocytes into the meningeal cavities of dogs, simultaneously with the inoculation of the meninges with tubercle bacilli, causes a slight delay in the development of the paralytic symptoms in about half the treated animals. This delay, however, is very slight when compared with the remarkable prolongation of the latent period previously observed after treatment with dog leucocytes. The injection of foreign leucocytes into the meningeal cavities of monkeys has thus far given almost uniformly negative results. In one small group of monkeys, however, inoculated by the method of lumbar puncture, the injection of rabbit leucocytes has been associated with a prolongation of the latent period in one of the treated monkeys, and with a complete prevention of the subsequent tuberculosis in a second monkey.
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spelling pubmed-21250202008-04-18 THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS Manwaring, Wilfred H. J Exp Med Article Rabbit leucocytes, injected into the basal meninges of dogs, in doses from 0.7 to one cubic centimeter apparently invariably cause death. Horse leucocytes, injected in the same amounts, cause death in about 25 per cent. of the dogs. . The injection of foreign leucocytes into the meninges of monkeys causes few if any symptoms. The injection of from one to three cubic centimeters of horse leucocytes into the meningeal cavities of dogs, simultaneously with the inoculation of the meninges with tubercle bacilli, causes a slight delay in the development of the paralytic symptoms in about half the treated animals. This delay, however, is very slight when compared with the remarkable prolongation of the latent period previously observed after treatment with dog leucocytes. The injection of foreign leucocytes into the meningeal cavities of monkeys has thus far given almost uniformly negative results. In one small group of monkeys, however, inoculated by the method of lumbar puncture, the injection of rabbit leucocytes has been associated with a prolongation of the latent period in one of the treated monkeys, and with a complete prevention of the subsequent tuberculosis in a second monkey. The Rockefeller University Press 1913-01-01 /pmc/articles/PMC2125020/ /pubmed/19867619 Text en Copyright © Copyright, 1913, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Manwaring, Wilfred H.
THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
title THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
title_full THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
title_fullStr THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
title_full_unstemmed THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
title_short THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
title_sort effects of subdural injections of leucocytes on the development and course of experimental tuberculous meningitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125020/
https://www.ncbi.nlm.nih.gov/pubmed/19867619
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