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A CONTRIBUTION TO THE PATHOLOGY OF EPIDEMIC POLIOMYELITIS

The virus of poliomyelitis is neurotropic, and localizes, and probably is capable of multiplying in the extramedullary parenchymatous nervous organs. It has been demonstrated by inoculation tests in the intervertebral, Gasserian, and abdominal sympathetic ganglia. All the ganglia show histological l...

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Autores principales: Flexner, Simon, Clark, Paul F., Amoss, Harold L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1914
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125147/
https://www.ncbi.nlm.nih.gov/pubmed/19867759
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author Flexner, Simon
Clark, Paul F.
Amoss, Harold L.
author_facet Flexner, Simon
Clark, Paul F.
Amoss, Harold L.
author_sort Flexner, Simon
collection PubMed
description The virus of poliomyelitis is neurotropic, and localizes, and probably is capable of multiplying in the extramedullary parenchymatous nervous organs. It has been demonstrated by inoculation tests in the intervertebral, Gasserian, and abdominal sympathetic ganglia. All the ganglia show histological lesions, more or less severe, similar to those of the spinal cord and brain. The severest occur in the intervertebral ganglia, those next in severity in the Gasserian, while the mildest appear in the abdominal sympathetic ganglia. The interstitial lesions predominate over the parenchymatous, and in preparalytic stages the intervertebral ganglia show interstitial lesions, especially pronounced at the pial covering. Epidemic poliomyelitis is a general disease of the nervous system, although the most prominent and important symptoms are those following injury to the motor neurones of the spinal cord and brain. The virus of poliomyelitis is highly resistant to glycerin, in which it survives for more than two years; to 0.5 per cent. phenol, in which it survives for more than one year; while it succumbs after having been kept frozen constantly for several months. It is unsafe to employ phenol to modify the virus of poliomyelitis for the purpose of active immunization. The cerebrospinal fluid of convalescents tends to be devoid of the neutralizing immunity principles for the virus of poliomyelitis, although they may exceptionally be present within this fluid. Doubtless the immunity principles are not produced locally in the nervous tissues, but elsewhere in the body, and are carried to the nervous organs by the blood.
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spelling pubmed-21251472008-04-18 A CONTRIBUTION TO THE PATHOLOGY OF EPIDEMIC POLIOMYELITIS Flexner, Simon Clark, Paul F. Amoss, Harold L. J Exp Med Article The virus of poliomyelitis is neurotropic, and localizes, and probably is capable of multiplying in the extramedullary parenchymatous nervous organs. It has been demonstrated by inoculation tests in the intervertebral, Gasserian, and abdominal sympathetic ganglia. All the ganglia show histological lesions, more or less severe, similar to those of the spinal cord and brain. The severest occur in the intervertebral ganglia, those next in severity in the Gasserian, while the mildest appear in the abdominal sympathetic ganglia. The interstitial lesions predominate over the parenchymatous, and in preparalytic stages the intervertebral ganglia show interstitial lesions, especially pronounced at the pial covering. Epidemic poliomyelitis is a general disease of the nervous system, although the most prominent and important symptoms are those following injury to the motor neurones of the spinal cord and brain. The virus of poliomyelitis is highly resistant to glycerin, in which it survives for more than two years; to 0.5 per cent. phenol, in which it survives for more than one year; while it succumbs after having been kept frozen constantly for several months. It is unsafe to employ phenol to modify the virus of poliomyelitis for the purpose of active immunization. The cerebrospinal fluid of convalescents tends to be devoid of the neutralizing immunity principles for the virus of poliomyelitis, although they may exceptionally be present within this fluid. Doubtless the immunity principles are not produced locally in the nervous tissues, but elsewhere in the body, and are carried to the nervous organs by the blood. The Rockefeller University Press 1914-02-01 /pmc/articles/PMC2125147/ /pubmed/19867759 Text en Copyright © Copyright, 1914, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Flexner, Simon
Clark, Paul F.
Amoss, Harold L.
A CONTRIBUTION TO THE PATHOLOGY OF EPIDEMIC POLIOMYELITIS
title A CONTRIBUTION TO THE PATHOLOGY OF EPIDEMIC POLIOMYELITIS
title_full A CONTRIBUTION TO THE PATHOLOGY OF EPIDEMIC POLIOMYELITIS
title_fullStr A CONTRIBUTION TO THE PATHOLOGY OF EPIDEMIC POLIOMYELITIS
title_full_unstemmed A CONTRIBUTION TO THE PATHOLOGY OF EPIDEMIC POLIOMYELITIS
title_short A CONTRIBUTION TO THE PATHOLOGY OF EPIDEMIC POLIOMYELITIS
title_sort contribution to the pathology of epidemic poliomyelitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125147/
https://www.ncbi.nlm.nih.gov/pubmed/19867759
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