A NOTE ON NITROGEN RETENTION FOLLOWING REPEATED INJECTIONS OF NEPHROTOXIC AGENTS

It is possible by means of repeated injections of uranium nitrate to produce in the cat a subacute or chronic nephritis which can progress to a fatal termination and show in its course increasing accumulation of non-protein nitrogen in the blood. This nephritis differs only slightly from the spontan...

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Detalles Bibliográficos
Autores principales: Karsner, Howard T., Denis, W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1914
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125158/
https://www.ncbi.nlm.nih.gov/pubmed/19867767
Descripción
Sumario:It is possible by means of repeated injections of uranium nitrate to produce in the cat a subacute or chronic nephritis which can progress to a fatal termination and show in its course increasing accumulation of non-protein nitrogen in the blood. This nephritis differs only slightly from the spontaneous chronic nephritis of the species. Repeated doses of diphtheria toxin produce a subacute form of nephritis with only temporary or slight retention, but nevertheless anatomically a well defined nephritis. The spontaneous nephritis studied resembles more closely that produced by uranium nitrate than that produced by diphtheria toxin both histologically and from the standpoint of blood analysis.

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