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THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : IX. THE CHANGES IN THE BONE MARROW AFTER SPLENECTOMY.

Splenectomy in the dog causes, as a rule, a transformation of the fatty marrow of the long bones to a richly cellular red marrow. During the early periods, one to three months, the change in the marrow is slight and either focal or peripheral; after six to twenty months the replacement of fat by mar...

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Detalles Bibliográficos
Autores principales: Pearce, Richard M., Pepper, O. H. Perry
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1914
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125180/
https://www.ncbi.nlm.nih.gov/pubmed/19867799
Descripción
Sumario:Splenectomy in the dog causes, as a rule, a transformation of the fatty marrow of the long bones to a richly cellular red marrow. During the early periods, one to three months, the change in the marrow is slight and either focal or peripheral; after six to twenty months the replacement of fat by marrow cells is complete or nearly so. Exceptions were, however, seen in four animals representing the 8th, 9th, 10th, and 22d months, respectively. The evidence at hand does not support the theory that this hyperplasia is compensatory either to the anemia caused by splenectomy or to an increased hemolysis in the lymph nodes. It is possible that it may be a concomitant of the activity of the bone marrow in taking over, in the absence of the spleen, the function of storing and elaborating the iron of old blood pigment for future utilization by new red cells, but our studies do not fully support this view.