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FREE MALARIAL PARASITES AND THE EFFECT OF THE MIGRATION OF THE PARASITES OF TERTIAN MALARIAL INFECTIONS

1. The malarial parasite is extracellular throughout its life cycle and migrates from red corpuscle to red corpuscle destroying each before it abandons it; in the brief intervals between, the parasite is free in the blood serum; it does not remain long free, but almost immediately attaches itself to...

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Autor principal: Lawson, Mary R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1914
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125224/
https://www.ncbi.nlm.nih.gov/pubmed/19867790
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author Lawson, Mary R.
author_facet Lawson, Mary R.
author_sort Lawson, Mary R.
collection PubMed
description 1. The malarial parasite is extracellular throughout its life cycle and migrates from red corpuscle to red corpuscle destroying each before it abandons it; in the brief intervals between, the parasite is free in the blood serum; it does not remain long free, but almost immediately attaches itself to another red corpuscle by means of delicate pseudopodia. 2. The compact form of the tertian parasite is the type of free parasite most often observed; in this form the parasite may be seen not only in migration, but after quinine and in the cadaver. I believe the compact form to be the normal resting form of the parasite, all other forms being assumed in order to secure attachment and to obtain food. 3. Care must be taken not to confound free parasites having protoplasmic pseudopodia ready for attachment with the sexual flagellating parasites, whose flagella are composed of chromatin. 4. The malarial parasite can live for some time free in the blood serum, though under normal conditions there is no reason why it should remain free for any length of time, and there are certain periods in the life of the parasite when it must be admitted that it is free from the corpuscle and survives. If the parasite is, as I believe, attached to the external surface of the red corpuscle, it is constantly exposed to the action of the patients' serum. 5. The destruction of more than one red corpuscle by each parasite would readily account for the severe and early anemia occurring in malarial infections. 6. Long continued treatment with quinine will eventually cause the death of all malarial parasites.
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spelling pubmed-21252242008-04-18 FREE MALARIAL PARASITES AND THE EFFECT OF THE MIGRATION OF THE PARASITES OF TERTIAN MALARIAL INFECTIONS Lawson, Mary R. J Exp Med Article 1. The malarial parasite is extracellular throughout its life cycle and migrates from red corpuscle to red corpuscle destroying each before it abandons it; in the brief intervals between, the parasite is free in the blood serum; it does not remain long free, but almost immediately attaches itself to another red corpuscle by means of delicate pseudopodia. 2. The compact form of the tertian parasite is the type of free parasite most often observed; in this form the parasite may be seen not only in migration, but after quinine and in the cadaver. I believe the compact form to be the normal resting form of the parasite, all other forms being assumed in order to secure attachment and to obtain food. 3. Care must be taken not to confound free parasites having protoplasmic pseudopodia ready for attachment with the sexual flagellating parasites, whose flagella are composed of chromatin. 4. The malarial parasite can live for some time free in the blood serum, though under normal conditions there is no reason why it should remain free for any length of time, and there are certain periods in the life of the parasite when it must be admitted that it is free from the corpuscle and survives. If the parasite is, as I believe, attached to the external surface of the red corpuscle, it is constantly exposed to the action of the patients' serum. 5. The destruction of more than one red corpuscle by each parasite would readily account for the severe and early anemia occurring in malarial infections. 6. Long continued treatment with quinine will eventually cause the death of all malarial parasites. The Rockefeller University Press 1914-06-01 /pmc/articles/PMC2125224/ /pubmed/19867790 Text en Copyright © Copyright, 1914, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Lawson, Mary R.
FREE MALARIAL PARASITES AND THE EFFECT OF THE MIGRATION OF THE PARASITES OF TERTIAN MALARIAL INFECTIONS
title FREE MALARIAL PARASITES AND THE EFFECT OF THE MIGRATION OF THE PARASITES OF TERTIAN MALARIAL INFECTIONS
title_full FREE MALARIAL PARASITES AND THE EFFECT OF THE MIGRATION OF THE PARASITES OF TERTIAN MALARIAL INFECTIONS
title_fullStr FREE MALARIAL PARASITES AND THE EFFECT OF THE MIGRATION OF THE PARASITES OF TERTIAN MALARIAL INFECTIONS
title_full_unstemmed FREE MALARIAL PARASITES AND THE EFFECT OF THE MIGRATION OF THE PARASITES OF TERTIAN MALARIAL INFECTIONS
title_short FREE MALARIAL PARASITES AND THE EFFECT OF THE MIGRATION OF THE PARASITES OF TERTIAN MALARIAL INFECTIONS
title_sort free malarial parasites and the effect of the migration of the parasites of tertian malarial infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125224/
https://www.ncbi.nlm.nih.gov/pubmed/19867790
work_keys_str_mv AT lawsonmaryr freemalarialparasitesandtheeffectofthemigrationoftheparasitesoftertianmalarialinfections