A TEST FOR ANTITHROMBIN IN THE BLOOD

A test is described for the estimation of antithrombin in the blood. The chief advantage of the test is that it is simple, and does not require the preparation of fibrinogen and of thrombin, which are difficult to prepare and to maintain in a pure state. The principle consists in titrating the antit...

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Detalles Bibliográficos
Autor principal: Hess, Alfred F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1915
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125317/
https://www.ncbi.nlm.nih.gov/pubmed/19867876
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author Hess, Alfred F.
author_facet Hess, Alfred F.
author_sort Hess, Alfred F.
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description A test is described for the estimation of antithrombin in the blood. The chief advantage of the test is that it is simple, and does not require the preparation of fibrinogen and of thrombin, which are difficult to prepare and to maintain in a pure state. The principle consists in titrating the antithrombin against normal human plasma; in this way we obtain an estimation of its power to delay coagulation. As the result of examinations carried out by this method, it would seem that there is a wide factor of safety as regards the amount of antithrombin in the human blood, and that this inhibiting substance may be increased to a considerable degree without markedly delaying or endangering clotting.
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spelling pubmed-21253172008-04-18 A TEST FOR ANTITHROMBIN IN THE BLOOD Hess, Alfred F. J Exp Med Article A test is described for the estimation of antithrombin in the blood. The chief advantage of the test is that it is simple, and does not require the preparation of fibrinogen and of thrombin, which are difficult to prepare and to maintain in a pure state. The principle consists in titrating the antithrombin against normal human plasma; in this way we obtain an estimation of its power to delay coagulation. As the result of examinations carried out by this method, it would seem that there is a wide factor of safety as regards the amount of antithrombin in the human blood, and that this inhibiting substance may be increased to a considerable degree without markedly delaying or endangering clotting. The Rockefeller University Press 1915-04-01 /pmc/articles/PMC2125317/ /pubmed/19867876 Text en Copyright © Copyright, 1915, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Hess, Alfred F.
A TEST FOR ANTITHROMBIN IN THE BLOOD
title A TEST FOR ANTITHROMBIN IN THE BLOOD
title_full A TEST FOR ANTITHROMBIN IN THE BLOOD
title_fullStr A TEST FOR ANTITHROMBIN IN THE BLOOD
title_full_unstemmed A TEST FOR ANTITHROMBIN IN THE BLOOD
title_short A TEST FOR ANTITHROMBIN IN THE BLOOD
title_sort test for antithrombin in the blood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125317/
https://www.ncbi.nlm.nih.gov/pubmed/19867876
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