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STUDIES UPON EXPERIMENTAL PNEUMONIA IN RABBITS : VIII. INTRA VITAM STAINING IN EXPERIMENTAL PNEUMONIA, AND THE CIRCULATION IN THE PNEUMONIC LUNG.

1. Dead leucocytes are constantly found in the pneumonic exudate. They rapidly undergo disintegration. Up to the seventh day they do not form the majority of the cells of the exudate. 2. Polymorphonuclear leucocytes with vitally stained granules are present in the exudate, vessels, and interstitial...

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Detalles Bibliográficos
Autores principales: Kline, B. S., Winternitz, M. C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1915
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125322/
https://www.ncbi.nlm.nih.gov/pubmed/19867873
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author Kline, B. S.
Winternitz, M. C.
author_facet Kline, B. S.
Winternitz, M. C.
author_sort Kline, B. S.
collection PubMed
description 1. Dead leucocytes are constantly found in the pneumonic exudate. They rapidly undergo disintegration. Up to the seventh day they do not form the majority of the cells of the exudate. 2. Polymorphonuclear leucocytes with vitally stained granules are present in the exudate, vessels, and interstitial tissue of the lung in experimental pneumonia, but they are not demonstrable in the general circulation in the same animals. 3. There is a marked impairment of the circulation in the pneumonic lung. 4. The increase in the intra-alveolar pressure exerted by the exudate has no influence upon the circulation. 5. The impaired circulation results from the wide distribution of capillary fibrin thrombi. In man these are, as a rule, distributed with relative uniformity. In the rabbit this is not usually the case. The thrombi are much more abundant in some areas and may lead to localized necrosis. 6. The impairment of the circulation is of importance in bringing about resolution. Only enough blood is allowed to seep through the vessels to nourish the alveolar walls. Consequently very little serum escapes into the alveoli and the autolysis of the exudate by the leucocytes is unhindered. 7. The impairment of the circulation in the pneumonic lung seriously interferes with the action of intravenous therapy upon the local lesion. 8. The exudate in the pneumonic lung can be readily impregnated with a dye injected intrabronchially. This suggests a method of administration of therapeutic agents in pneumonia.
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spelling pubmed-21253222008-04-18 STUDIES UPON EXPERIMENTAL PNEUMONIA IN RABBITS : VIII. INTRA VITAM STAINING IN EXPERIMENTAL PNEUMONIA, AND THE CIRCULATION IN THE PNEUMONIC LUNG. Kline, B. S. Winternitz, M. C. J Exp Med Article 1. Dead leucocytes are constantly found in the pneumonic exudate. They rapidly undergo disintegration. Up to the seventh day they do not form the majority of the cells of the exudate. 2. Polymorphonuclear leucocytes with vitally stained granules are present in the exudate, vessels, and interstitial tissue of the lung in experimental pneumonia, but they are not demonstrable in the general circulation in the same animals. 3. There is a marked impairment of the circulation in the pneumonic lung. 4. The increase in the intra-alveolar pressure exerted by the exudate has no influence upon the circulation. 5. The impaired circulation results from the wide distribution of capillary fibrin thrombi. In man these are, as a rule, distributed with relative uniformity. In the rabbit this is not usually the case. The thrombi are much more abundant in some areas and may lead to localized necrosis. 6. The impairment of the circulation is of importance in bringing about resolution. Only enough blood is allowed to seep through the vessels to nourish the alveolar walls. Consequently very little serum escapes into the alveoli and the autolysis of the exudate by the leucocytes is unhindered. 7. The impairment of the circulation in the pneumonic lung seriously interferes with the action of intravenous therapy upon the local lesion. 8. The exudate in the pneumonic lung can be readily impregnated with a dye injected intrabronchially. This suggests a method of administration of therapeutic agents in pneumonia. The Rockefeller University Press 1915-04-01 /pmc/articles/PMC2125322/ /pubmed/19867873 Text en Copyright © Copyright, 1915, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Kline, B. S.
Winternitz, M. C.
STUDIES UPON EXPERIMENTAL PNEUMONIA IN RABBITS : VIII. INTRA VITAM STAINING IN EXPERIMENTAL PNEUMONIA, AND THE CIRCULATION IN THE PNEUMONIC LUNG.
title STUDIES UPON EXPERIMENTAL PNEUMONIA IN RABBITS : VIII. INTRA VITAM STAINING IN EXPERIMENTAL PNEUMONIA, AND THE CIRCULATION IN THE PNEUMONIC LUNG.
title_full STUDIES UPON EXPERIMENTAL PNEUMONIA IN RABBITS : VIII. INTRA VITAM STAINING IN EXPERIMENTAL PNEUMONIA, AND THE CIRCULATION IN THE PNEUMONIC LUNG.
title_fullStr STUDIES UPON EXPERIMENTAL PNEUMONIA IN RABBITS : VIII. INTRA VITAM STAINING IN EXPERIMENTAL PNEUMONIA, AND THE CIRCULATION IN THE PNEUMONIC LUNG.
title_full_unstemmed STUDIES UPON EXPERIMENTAL PNEUMONIA IN RABBITS : VIII. INTRA VITAM STAINING IN EXPERIMENTAL PNEUMONIA, AND THE CIRCULATION IN THE PNEUMONIC LUNG.
title_short STUDIES UPON EXPERIMENTAL PNEUMONIA IN RABBITS : VIII. INTRA VITAM STAINING IN EXPERIMENTAL PNEUMONIA, AND THE CIRCULATION IN THE PNEUMONIC LUNG.
title_sort studies upon experimental pneumonia in rabbits : viii. intra vitam staining in experimental pneumonia, and the circulation in the pneumonic lung.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125322/
https://www.ncbi.nlm.nih.gov/pubmed/19867873
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