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CONCERNING CHANGES IN THE BIOLOGICAL PROPERTIES OF TRYPANOSOMA LEWISI PRODUCED BY EXPERIMENTAL MEANS, WITH ESPECIAL REFERENCE TO VIRULENCE
1. Different strains of Trypanosoma lewisi represent different states of biological balance, especially between the powers of propagation and resistance to destruction. 2. The biological status of a given strain of Trypanosoma lewisi is subject to cyclic variations as the result of immunological rea...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1915
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125323/ https://www.ncbi.nlm.nih.gov/pubmed/19867877 |
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author | Brown, Wade H. |
author_facet | Brown, Wade H. |
author_sort | Brown, Wade H. |
collection | PubMed |
description | 1. Different strains of Trypanosoma lewisi represent different states of biological balance, especially between the powers of propagation and resistance to destruction. 2. The biological status of a given strain of Trypanosoma lewisi is subject to cyclic variations as the result of immunological reactions in the blood of the host. 3. The factors limiting reproduction and causing destruction of Trypanosoma lewisi in the blood are appreciably independent of each other. It is possible, therefore, to influence these processes separately and even in opposite directions. 4. The virulence of Trypanosoma lewisi, manifested in its highest form, is dependent upon some degree of reproductive fastness, strong antigenic action, and susceptibility to destruction, varying degrees in the development of these properties producing corresponding variations in the degree of virulence. 5. By a properly regulated system of passage the properties of Trypanosoma lewisi that determine its infection cycle and its virulence may be eventually so altered as to change completely both the nature and course of the infection. Such a system of passage must be adapted to the particular strain of Trypanosoma lewisi used. 6. Immunological reactions exercise a dominant influence in determining the ultimate biological variations of Trypanosoma lewisi. |
format | Text |
id | pubmed-2125323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1915 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21253232008-04-18 CONCERNING CHANGES IN THE BIOLOGICAL PROPERTIES OF TRYPANOSOMA LEWISI PRODUCED BY EXPERIMENTAL MEANS, WITH ESPECIAL REFERENCE TO VIRULENCE Brown, Wade H. J Exp Med Article 1. Different strains of Trypanosoma lewisi represent different states of biological balance, especially between the powers of propagation and resistance to destruction. 2. The biological status of a given strain of Trypanosoma lewisi is subject to cyclic variations as the result of immunological reactions in the blood of the host. 3. The factors limiting reproduction and causing destruction of Trypanosoma lewisi in the blood are appreciably independent of each other. It is possible, therefore, to influence these processes separately and even in opposite directions. 4. The virulence of Trypanosoma lewisi, manifested in its highest form, is dependent upon some degree of reproductive fastness, strong antigenic action, and susceptibility to destruction, varying degrees in the development of these properties producing corresponding variations in the degree of virulence. 5. By a properly regulated system of passage the properties of Trypanosoma lewisi that determine its infection cycle and its virulence may be eventually so altered as to change completely both the nature and course of the infection. Such a system of passage must be adapted to the particular strain of Trypanosoma lewisi used. 6. Immunological reactions exercise a dominant influence in determining the ultimate biological variations of Trypanosoma lewisi. The Rockefeller University Press 1915-04-01 /pmc/articles/PMC2125323/ /pubmed/19867877 Text en Copyright © Copyright, 1915, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Brown, Wade H. CONCERNING CHANGES IN THE BIOLOGICAL PROPERTIES OF TRYPANOSOMA LEWISI PRODUCED BY EXPERIMENTAL MEANS, WITH ESPECIAL REFERENCE TO VIRULENCE |
title | CONCERNING CHANGES IN THE BIOLOGICAL PROPERTIES OF TRYPANOSOMA LEWISI PRODUCED BY EXPERIMENTAL MEANS, WITH ESPECIAL REFERENCE TO VIRULENCE |
title_full | CONCERNING CHANGES IN THE BIOLOGICAL PROPERTIES OF TRYPANOSOMA LEWISI PRODUCED BY EXPERIMENTAL MEANS, WITH ESPECIAL REFERENCE TO VIRULENCE |
title_fullStr | CONCERNING CHANGES IN THE BIOLOGICAL PROPERTIES OF TRYPANOSOMA LEWISI PRODUCED BY EXPERIMENTAL MEANS, WITH ESPECIAL REFERENCE TO VIRULENCE |
title_full_unstemmed | CONCERNING CHANGES IN THE BIOLOGICAL PROPERTIES OF TRYPANOSOMA LEWISI PRODUCED BY EXPERIMENTAL MEANS, WITH ESPECIAL REFERENCE TO VIRULENCE |
title_short | CONCERNING CHANGES IN THE BIOLOGICAL PROPERTIES OF TRYPANOSOMA LEWISI PRODUCED BY EXPERIMENTAL MEANS, WITH ESPECIAL REFERENCE TO VIRULENCE |
title_sort | concerning changes in the biological properties of trypanosoma lewisi produced by experimental means, with especial reference to virulence |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125323/ https://www.ncbi.nlm.nih.gov/pubmed/19867877 |
work_keys_str_mv | AT brownwadeh concerningchangesinthebiologicalpropertiesoftrypanosomalewisiproducedbyexperimentalmeanswithespecialreferencetovirulence |