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THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : THIRD PAPER.

Experiments are reported which show that in all probability the increased resistance to tuberculous infection which is imparted to mice by the removal of the spleen is a consequence of the loss of a function of the organ. This function can be restored by the feeding of fresh spleen. For the present...

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Detalles Bibliográficos
Autores principales: Lewis, Paul A., Margot, Arthur Georges
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1915
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125336/
https://www.ncbi.nlm.nih.gov/pubmed/19867922
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author Lewis, Paul A.
Margot, Arthur Georges
author_facet Lewis, Paul A.
Margot, Arthur Georges
author_sort Lewis, Paul A.
collection PubMed
description Experiments are reported which show that in all probability the increased resistance to tuberculous infection which is imparted to mice by the removal of the spleen is a consequence of the loss of a function of the organ. This function can be restored by the feeding of fresh spleen. For the present we attribute these changes to the removal and restoration, as the case may be, of a particular substance for which the designation tuberculosplenatin is suggested. This substance is assumed to be related to the spleen as adrenalin is related to the adrenal gland. It is peculiar to the organ but not to the species. It is not found in other organs of the body so far as our observations have extended. The absence of the substance from the lymphatic glands seems of especial importance in this connection.
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spelling pubmed-21253362008-04-18 THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : THIRD PAPER. Lewis, Paul A. Margot, Arthur Georges J Exp Med Article Experiments are reported which show that in all probability the increased resistance to tuberculous infection which is imparted to mice by the removal of the spleen is a consequence of the loss of a function of the organ. This function can be restored by the feeding of fresh spleen. For the present we attribute these changes to the removal and restoration, as the case may be, of a particular substance for which the designation tuberculosplenatin is suggested. This substance is assumed to be related to the spleen as adrenalin is related to the adrenal gland. It is peculiar to the organ but not to the species. It is not found in other organs of the body so far as our observations have extended. The absence of the substance from the lymphatic glands seems of especial importance in this connection. The Rockefeller University Press 1915-09-01 /pmc/articles/PMC2125336/ /pubmed/19867922 Text en Copyright © Copyright, 1915, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Lewis, Paul A.
Margot, Arthur Georges
THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : THIRD PAPER.
title THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : THIRD PAPER.
title_full THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : THIRD PAPER.
title_fullStr THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : THIRD PAPER.
title_full_unstemmed THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : THIRD PAPER.
title_short THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : THIRD PAPER.
title_sort function of the spleen in the experimental infection of albino mice with bacillus tuberculosis : third paper.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125336/
https://www.ncbi.nlm.nih.gov/pubmed/19867922
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