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A FURTHER STUDY OF THE BACTERICIDAL ACTION OF ETHYLHYDROCUPREIN ON PNEUMOCOCCI
1. The serum of rabbits which have been previously treated with a single dose of ethylhydrocuprein (optochin) exerts a bactericidal action on, and, later, inhibits the growth of pneumococci in the test-tube. 2. These actions are most evident in the serum of rabbits when the base (optochin base) is g...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1915
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125370/ https://www.ncbi.nlm.nih.gov/pubmed/19867938 |
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author | Moore, Henry F. |
author_facet | Moore, Henry F. |
author_sort | Moore, Henry F. |
collection | PubMed |
description | 1. The serum of rabbits which have been previously treated with a single dose of ethylhydrocuprein (optochin) exerts a bactericidal action on, and, later, inhibits the growth of pneumococci in the test-tube. 2. These actions are most evident in the serum of rabbits when the base (optochin base) is given in oil subcutaneously; somewhat less when the hydrochloride of the drug is given in water subcutaneously; slight when the base is given in oil intramuscularly; and least evident, or absent, when the hydrochloride in water is introduced directly into the stomach. To get these effects by the intravenous route, toxic doses must be given, and, even with toxic non-fatal doses, the effects do not last long. 3. In the case of the base given in oil subcutaneously to rabbits in a dosage of 0.1 gram per kilo of body weight, the bactericidal action of the serum is at its maximum about one hour after administration, and it passes into an inhibitory effect about four hours after the drug has been given. 4. In man the same inhibitory and bactericidal actions of the serum are present when a single dose of 0.5 gram of the hydrochloride of the drug is given by the mouth or subcutaneously, but the bactericidal action is not so marked as in rabbits. 5. When the optochin concentration in the serum has, apparently,. diminished to a certain point in relation to the number of pneumococci present, the pneumococci which have survived the bactericidal action for a few hours acquire the power of growing freely. |
format | Text |
id | pubmed-2125370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1915 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21253702008-04-18 A FURTHER STUDY OF THE BACTERICIDAL ACTION OF ETHYLHYDROCUPREIN ON PNEUMOCOCCI Moore, Henry F. J Exp Med Article 1. The serum of rabbits which have been previously treated with a single dose of ethylhydrocuprein (optochin) exerts a bactericidal action on, and, later, inhibits the growth of pneumococci in the test-tube. 2. These actions are most evident in the serum of rabbits when the base (optochin base) is given in oil subcutaneously; somewhat less when the hydrochloride of the drug is given in water subcutaneously; slight when the base is given in oil intramuscularly; and least evident, or absent, when the hydrochloride in water is introduced directly into the stomach. To get these effects by the intravenous route, toxic doses must be given, and, even with toxic non-fatal doses, the effects do not last long. 3. In the case of the base given in oil subcutaneously to rabbits in a dosage of 0.1 gram per kilo of body weight, the bactericidal action of the serum is at its maximum about one hour after administration, and it passes into an inhibitory effect about four hours after the drug has been given. 4. In man the same inhibitory and bactericidal actions of the serum are present when a single dose of 0.5 gram of the hydrochloride of the drug is given by the mouth or subcutaneously, but the bactericidal action is not so marked as in rabbits. 5. When the optochin concentration in the serum has, apparently,. diminished to a certain point in relation to the number of pneumococci present, the pneumococci which have survived the bactericidal action for a few hours acquire the power of growing freely. The Rockefeller University Press 1915-11-01 /pmc/articles/PMC2125370/ /pubmed/19867938 Text en Copyright © Copyright, 1915, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Moore, Henry F. A FURTHER STUDY OF THE BACTERICIDAL ACTION OF ETHYLHYDROCUPREIN ON PNEUMOCOCCI |
title | A FURTHER STUDY OF THE BACTERICIDAL ACTION OF ETHYLHYDROCUPREIN ON PNEUMOCOCCI |
title_full | A FURTHER STUDY OF THE BACTERICIDAL ACTION OF ETHYLHYDROCUPREIN ON PNEUMOCOCCI |
title_fullStr | A FURTHER STUDY OF THE BACTERICIDAL ACTION OF ETHYLHYDROCUPREIN ON PNEUMOCOCCI |
title_full_unstemmed | A FURTHER STUDY OF THE BACTERICIDAL ACTION OF ETHYLHYDROCUPREIN ON PNEUMOCOCCI |
title_short | A FURTHER STUDY OF THE BACTERICIDAL ACTION OF ETHYLHYDROCUPREIN ON PNEUMOCOCCI |
title_sort | further study of the bactericidal action of ethylhydrocuprein on pneumococci |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125370/ https://www.ncbi.nlm.nih.gov/pubmed/19867938 |
work_keys_str_mv | AT moorehenryf afurtherstudyofthebactericidalactionofethylhydrocupreinonpneumococci AT moorehenryf furtherstudyofthebactericidalactionofethylhydrocupreinonpneumococci |