CHEMOPATHOLOGICAL STUDIES WITH COMPOUNDS OF ARSENIC : III. ON THE PATHOLOGICAL ACTION OF ARSENICALS ON THE ADRENALS.

1. Toxic doses of all arsenicals of which we have any knowledge produce definite pathological changes in the adrenals of guinea pigs. These changes include congestion, hemorrhage, disturbances in the lipoid content, cellular degenerations and necroses, and reduction in the chromaffin content. 2. The...

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Detalles Bibliográficos
Autores principales: Brown, Wade H., Pearce, Louise
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1915
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125372/
https://www.ncbi.nlm.nih.gov/pubmed/19867936
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author Brown, Wade H.
Pearce, Louise
author_facet Brown, Wade H.
Pearce, Louise
author_sort Brown, Wade H.
collection PubMed
description 1. Toxic doses of all arsenicals of which we have any knowledge produce definite pathological changes in the adrenals of guinea pigs. These changes include congestion, hemorrhage, disturbances in the lipoid content, cellular degenerations and necroses, and reduction in the chromaffin content. 2. The character and severity of the injury produced by different arsenicals varies with the chemical constitution of the compounds. 3. From these facts, we believe that adrenal injury is an important factor in arsenical intoxication and suggest that therapeutic doses of some arsenicals may produce adrenal stimulation.
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spelling pubmed-21253722008-04-18 CHEMOPATHOLOGICAL STUDIES WITH COMPOUNDS OF ARSENIC : III. ON THE PATHOLOGICAL ACTION OF ARSENICALS ON THE ADRENALS. Brown, Wade H. Pearce, Louise J Exp Med Article 1. Toxic doses of all arsenicals of which we have any knowledge produce definite pathological changes in the adrenals of guinea pigs. These changes include congestion, hemorrhage, disturbances in the lipoid content, cellular degenerations and necroses, and reduction in the chromaffin content. 2. The character and severity of the injury produced by different arsenicals varies with the chemical constitution of the compounds. 3. From these facts, we believe that adrenal injury is an important factor in arsenical intoxication and suggest that therapeutic doses of some arsenicals may produce adrenal stimulation. The Rockefeller University Press 1915-11-01 /pmc/articles/PMC2125372/ /pubmed/19867936 Text en Copyright © Copyright, 1915, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Brown, Wade H.
Pearce, Louise
CHEMOPATHOLOGICAL STUDIES WITH COMPOUNDS OF ARSENIC : III. ON THE PATHOLOGICAL ACTION OF ARSENICALS ON THE ADRENALS.
title CHEMOPATHOLOGICAL STUDIES WITH COMPOUNDS OF ARSENIC : III. ON THE PATHOLOGICAL ACTION OF ARSENICALS ON THE ADRENALS.
title_full CHEMOPATHOLOGICAL STUDIES WITH COMPOUNDS OF ARSENIC : III. ON THE PATHOLOGICAL ACTION OF ARSENICALS ON THE ADRENALS.
title_fullStr CHEMOPATHOLOGICAL STUDIES WITH COMPOUNDS OF ARSENIC : III. ON THE PATHOLOGICAL ACTION OF ARSENICALS ON THE ADRENALS.
title_full_unstemmed CHEMOPATHOLOGICAL STUDIES WITH COMPOUNDS OF ARSENIC : III. ON THE PATHOLOGICAL ACTION OF ARSENICALS ON THE ADRENALS.
title_short CHEMOPATHOLOGICAL STUDIES WITH COMPOUNDS OF ARSENIC : III. ON THE PATHOLOGICAL ACTION OF ARSENICALS ON THE ADRENALS.
title_sort chemopathological studies with compounds of arsenic : iii. on the pathological action of arsenicals on the adrenals.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125372/
https://www.ncbi.nlm.nih.gov/pubmed/19867936
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AT pearcelouise chemopathologicalstudieswithcompoundsofarseniciiionthepathologicalactionofarsenicalsontheadrenals

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