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VENOM HEMOLYSIS AFTER SPLENECTOMY, INCLUDING THE RESISTANCE OF THE ERYTHROCYTES OF NORMAL DOGS TO THE HEMOLYTIC ACTIVITY OF COBRA VENOM

1. The resistance of erythrocytes of dogs to the hemolytic activity of cobra venom is increased after splenectomy. 2. This increased resistance was observed as early as 4 days after splenectomy and usually persisted for a period of about 3 weeks, when the resistance gradually decreased to normal or...

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Autor principal: Kolmer, John A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1917
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125773/
https://www.ncbi.nlm.nih.gov/pubmed/19868082
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author Kolmer, John A.
author_facet Kolmer, John A.
author_sort Kolmer, John A.
collection PubMed
description 1. The resistance of erythrocytes of dogs to the hemolytic activity of cobra venom is increased after splenectomy. 2. This increased resistance was observed as early as 4 days after splenectomy and usually persisted for a period of about 3 weeks, when the resistance gradually decreased to normal or slightly beyond. 3. The decrease of resistance to the hemolytic activity of venom for the erythrocytes of splenectomized dogs following the primary increase is apparently coincident with the anemia following splenectomy. An intercurrent infection, such as distemper, tends to reduce the resistance of erythrocytes to venom. 4. An increased resistance of the erythrocytes to hypotonic salt solutions was found with all the splenectomized dogs in which these tests were made. Increased resistance to hypotonic salt solutions apparently persists for a longer period than the increased resistance to cobra venom. 5. As the lysis of erythrocytes by venom is dependent upon the presence of certain lipoidal substances within the cells, and as the spleen may exercise an influence over the lipoidal contents of corpuscles and serum, it is suggested that the increased resistance of erythrocytes to the hemolytic activity of venom after splenectomy is due to alterations in the lipoid content of the erythrocytes.
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spelling pubmed-21257732008-04-18 VENOM HEMOLYSIS AFTER SPLENECTOMY, INCLUDING THE RESISTANCE OF THE ERYTHROCYTES OF NORMAL DOGS TO THE HEMOLYTIC ACTIVITY OF COBRA VENOM Kolmer, John A. J Exp Med Article 1. The resistance of erythrocytes of dogs to the hemolytic activity of cobra venom is increased after splenectomy. 2. This increased resistance was observed as early as 4 days after splenectomy and usually persisted for a period of about 3 weeks, when the resistance gradually decreased to normal or slightly beyond. 3. The decrease of resistance to the hemolytic activity of venom for the erythrocytes of splenectomized dogs following the primary increase is apparently coincident with the anemia following splenectomy. An intercurrent infection, such as distemper, tends to reduce the resistance of erythrocytes to venom. 4. An increased resistance of the erythrocytes to hypotonic salt solutions was found with all the splenectomized dogs in which these tests were made. Increased resistance to hypotonic salt solutions apparently persists for a longer period than the increased resistance to cobra venom. 5. As the lysis of erythrocytes by venom is dependent upon the presence of certain lipoidal substances within the cells, and as the spleen may exercise an influence over the lipoidal contents of corpuscles and serum, it is suggested that the increased resistance of erythrocytes to the hemolytic activity of venom after splenectomy is due to alterations in the lipoid content of the erythrocytes. The Rockefeller University Press 1917-02-01 /pmc/articles/PMC2125773/ /pubmed/19868082 Text en Copyright © Copyright, 1917, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Kolmer, John A.
VENOM HEMOLYSIS AFTER SPLENECTOMY, INCLUDING THE RESISTANCE OF THE ERYTHROCYTES OF NORMAL DOGS TO THE HEMOLYTIC ACTIVITY OF COBRA VENOM
title VENOM HEMOLYSIS AFTER SPLENECTOMY, INCLUDING THE RESISTANCE OF THE ERYTHROCYTES OF NORMAL DOGS TO THE HEMOLYTIC ACTIVITY OF COBRA VENOM
title_full VENOM HEMOLYSIS AFTER SPLENECTOMY, INCLUDING THE RESISTANCE OF THE ERYTHROCYTES OF NORMAL DOGS TO THE HEMOLYTIC ACTIVITY OF COBRA VENOM
title_fullStr VENOM HEMOLYSIS AFTER SPLENECTOMY, INCLUDING THE RESISTANCE OF THE ERYTHROCYTES OF NORMAL DOGS TO THE HEMOLYTIC ACTIVITY OF COBRA VENOM
title_full_unstemmed VENOM HEMOLYSIS AFTER SPLENECTOMY, INCLUDING THE RESISTANCE OF THE ERYTHROCYTES OF NORMAL DOGS TO THE HEMOLYTIC ACTIVITY OF COBRA VENOM
title_short VENOM HEMOLYSIS AFTER SPLENECTOMY, INCLUDING THE RESISTANCE OF THE ERYTHROCYTES OF NORMAL DOGS TO THE HEMOLYTIC ACTIVITY OF COBRA VENOM
title_sort venom hemolysis after splenectomy, including the resistance of the erythrocytes of normal dogs to the hemolytic activity of cobra venom
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125773/
https://www.ncbi.nlm.nih.gov/pubmed/19868082
work_keys_str_mv AT kolmerjohna venomhemolysisaftersplenectomyincludingtheresistanceoftheerythrocytesofnormaldogstothehemolyticactivityofcobravenom