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THE ELIMINATION OF IRON AND ITS DISTRIBUTION IN THE LIVER AND SPLEEN IN EXPERIMENTAL ANEMIA. II

In the continuous blood destruction, essentially a chronic experimental anemia, caused by injecting the dog with Trypanosoma equiperdum, no increased elimination of iron is observed in the feces. The storage of iron in the liver and spleen under these experimental conditions is somewhat greater in a...

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Detalles Bibliográficos
Autores principales: Dubin, Harry, Pearce, Richard M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1918
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125946/
https://www.ncbi.nlm.nih.gov/pubmed/19868220
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author Dubin, Harry
Pearce, Richard M.
author_facet Dubin, Harry
Pearce, Richard M.
author_sort Dubin, Harry
collection PubMed
description In the continuous blood destruction, essentially a chronic experimental anemia, caused by injecting the dog with Trypanosoma equiperdum, no increased elimination of iron is observed in the feces. The storage of iron in the liver and spleen under these experimental conditions is somewhat greater in amount, but of the same general character as in transient experimental anemia. Splenectomy before or after infection, i.e. the development of anemia, influences neither the elimination of iron in the feces nor its storage in the liver. The retardation of the course of the trypanosome infection and thus the production of a more chronic anemia by treatment with a trypanocide, arsenobenzol, likewise does not affect iron storage. These experiments have therefore failed to reproduce the changes in iron metabolism seen in certain of the chronic hemolytic anemias of man. In the presence of a bile duct-ureter fistula the iroh content of the mixture of urine and bile is not appreciably greater than that of the urine alone. In the dog, therefore, the elimination of iron in the the bile would not appear to be an important factor. On the other hand, when bile is excluded from the intestine an unusual storage of iron occurs in the spleen. For this no explanation is offered.
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spelling pubmed-21259462008-04-18 THE ELIMINATION OF IRON AND ITS DISTRIBUTION IN THE LIVER AND SPLEEN IN EXPERIMENTAL ANEMIA. II Dubin, Harry Pearce, Richard M. J Exp Med Article In the continuous blood destruction, essentially a chronic experimental anemia, caused by injecting the dog with Trypanosoma equiperdum, no increased elimination of iron is observed in the feces. The storage of iron in the liver and spleen under these experimental conditions is somewhat greater in amount, but of the same general character as in transient experimental anemia. Splenectomy before or after infection, i.e. the development of anemia, influences neither the elimination of iron in the feces nor its storage in the liver. The retardation of the course of the trypanosome infection and thus the production of a more chronic anemia by treatment with a trypanocide, arsenobenzol, likewise does not affect iron storage. These experiments have therefore failed to reproduce the changes in iron metabolism seen in certain of the chronic hemolytic anemias of man. In the presence of a bile duct-ureter fistula the iroh content of the mixture of urine and bile is not appreciably greater than that of the urine alone. In the dog, therefore, the elimination of iron in the the bile would not appear to be an important factor. On the other hand, when bile is excluded from the intestine an unusual storage of iron occurs in the spleen. For this no explanation is offered. The Rockefeller University Press 1918-04-01 /pmc/articles/PMC2125946/ /pubmed/19868220 Text en Copyright © Copyright, 1918, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Dubin, Harry
Pearce, Richard M.
THE ELIMINATION OF IRON AND ITS DISTRIBUTION IN THE LIVER AND SPLEEN IN EXPERIMENTAL ANEMIA. II
title THE ELIMINATION OF IRON AND ITS DISTRIBUTION IN THE LIVER AND SPLEEN IN EXPERIMENTAL ANEMIA. II
title_full THE ELIMINATION OF IRON AND ITS DISTRIBUTION IN THE LIVER AND SPLEEN IN EXPERIMENTAL ANEMIA. II
title_fullStr THE ELIMINATION OF IRON AND ITS DISTRIBUTION IN THE LIVER AND SPLEEN IN EXPERIMENTAL ANEMIA. II
title_full_unstemmed THE ELIMINATION OF IRON AND ITS DISTRIBUTION IN THE LIVER AND SPLEEN IN EXPERIMENTAL ANEMIA. II
title_short THE ELIMINATION OF IRON AND ITS DISTRIBUTION IN THE LIVER AND SPLEEN IN EXPERIMENTAL ANEMIA. II
title_sort elimination of iron and its distribution in the liver and spleen in experimental anemia. ii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125946/
https://www.ncbi.nlm.nih.gov/pubmed/19868220
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