THE ACTION OF STROPHANTHIN ON THE LIVING CAT'S HEART

1. Cats vary considerably in their susceptibility to strophanthin and in the extent of the difference between the minimum lethal dose and the minimum toxic dose. 2. The amount of strophanthin necessary to produce a toxic effect in a given cat is independent of the speed of administration to a period...

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Detalles Bibliográficos
Autor principal: Levine, Samuel A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1919
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2126334/
https://www.ncbi.nlm.nih.gov/pubmed/19868332
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author Levine, Samuel A.
author_facet Levine, Samuel A.
author_sort Levine, Samuel A.
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description 1. Cats vary considerably in their susceptibility to strophanthin and in the extent of the difference between the minimum lethal dose and the minimum toxic dose. 2. The amount of strophanthin necessary to produce a toxic effect in a given cat is independent of the speed of administration to a period of 4 hours. An improvement in the clinical administration of the drug is thereby indicated. 3. A theory of the action of strophanthin is formulated which reconciles the results which point to the importance of the total amount taken up by the heart with those inidicate that the concentration of the drug is the determining factor.
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spelling pubmed-21263342008-04-18 THE ACTION OF STROPHANTHIN ON THE LIVING CAT'S HEART Levine, Samuel A. J Exp Med Article 1. Cats vary considerably in their susceptibility to strophanthin and in the extent of the difference between the minimum lethal dose and the minimum toxic dose. 2. The amount of strophanthin necessary to produce a toxic effect in a given cat is independent of the speed of administration to a period of 4 hours. An improvement in the clinical administration of the drug is thereby indicated. 3. A theory of the action of strophanthin is formulated which reconciles the results which point to the importance of the total amount taken up by the heart with those inidicate that the concentration of the drug is the determining factor. The Rockefeller University Press 1919-05-01 /pmc/articles/PMC2126334/ /pubmed/19868332 Text en Copyright © Copyright, 1919, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Levine, Samuel A.
THE ACTION OF STROPHANTHIN ON THE LIVING CAT'S HEART
title THE ACTION OF STROPHANTHIN ON THE LIVING CAT'S HEART
title_full THE ACTION OF STROPHANTHIN ON THE LIVING CAT'S HEART
title_fullStr THE ACTION OF STROPHANTHIN ON THE LIVING CAT'S HEART
title_full_unstemmed THE ACTION OF STROPHANTHIN ON THE LIVING CAT'S HEART
title_short THE ACTION OF STROPHANTHIN ON THE LIVING CAT'S HEART
title_sort action of strophanthin on the living cat's heart
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2126334/
https://www.ncbi.nlm.nih.gov/pubmed/19868332
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