COMPARISON OF THE POTENCY OF POLYVALENT ANTIMENINGOCOCCUS SERUM PRODUCED WITH FOUR AND SIX REPRESENTATIVE STRAINS AND THAT PRODUCED WITH SIXTY STRAINS, AS DETERMINED BY THE AGGLUTINATION TITER

The potency of a polyvalent antimeningococcus serum, as tested by its agglutination titer, was sacrificed by immunization with a large number of strains of the meningococcus. By immunization with a limited number of representative strains, four or six, carefully selected on account of their antigeni...

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Detalles Bibliográficos
Autor principal: Wadsworth, Augustus B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1921
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128163/
https://www.ncbi.nlm.nih.gov/pubmed/19868475
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author Wadsworth, Augustus B.
author_facet Wadsworth, Augustus B.
author_sort Wadsworth, Augustus B.
collection PubMed
description The potency of a polyvalent antimeningococcus serum, as tested by its agglutination titer, was sacrificed by immunization with a large number of strains of the meningococcus. By immunization with a limited number of representative strains, four or six, carefully selected on account of their antigenic and agglutination properties, the potency was increased three- to tenfold without sacrificing the polyvalency; that is, as tested with at least 70 heterologous strains of the meningococcus. The agglutination titer, unfortunately, is not an entirely satisfactory criterion of therapeutic potency, but it is the only practical method available that determines also the polyvalent action of antimeningococcus serum.
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spelling pubmed-21281632008-04-18 COMPARISON OF THE POTENCY OF POLYVALENT ANTIMENINGOCOCCUS SERUM PRODUCED WITH FOUR AND SIX REPRESENTATIVE STRAINS AND THAT PRODUCED WITH SIXTY STRAINS, AS DETERMINED BY THE AGGLUTINATION TITER Wadsworth, Augustus B. J Exp Med Article The potency of a polyvalent antimeningococcus serum, as tested by its agglutination titer, was sacrificed by immunization with a large number of strains of the meningococcus. By immunization with a limited number of representative strains, four or six, carefully selected on account of their antigenic and agglutination properties, the potency was increased three- to tenfold without sacrificing the polyvalency; that is, as tested with at least 70 heterologous strains of the meningococcus. The agglutination titer, unfortunately, is not an entirely satisfactory criterion of therapeutic potency, but it is the only practical method available that determines also the polyvalent action of antimeningococcus serum. The Rockefeller University Press 1921-01-01 /pmc/articles/PMC2128163/ /pubmed/19868475 Text en Copyright © Copyright, 1921, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Wadsworth, Augustus B.
COMPARISON OF THE POTENCY OF POLYVALENT ANTIMENINGOCOCCUS SERUM PRODUCED WITH FOUR AND SIX REPRESENTATIVE STRAINS AND THAT PRODUCED WITH SIXTY STRAINS, AS DETERMINED BY THE AGGLUTINATION TITER
title COMPARISON OF THE POTENCY OF POLYVALENT ANTIMENINGOCOCCUS SERUM PRODUCED WITH FOUR AND SIX REPRESENTATIVE STRAINS AND THAT PRODUCED WITH SIXTY STRAINS, AS DETERMINED BY THE AGGLUTINATION TITER
title_full COMPARISON OF THE POTENCY OF POLYVALENT ANTIMENINGOCOCCUS SERUM PRODUCED WITH FOUR AND SIX REPRESENTATIVE STRAINS AND THAT PRODUCED WITH SIXTY STRAINS, AS DETERMINED BY THE AGGLUTINATION TITER
title_fullStr COMPARISON OF THE POTENCY OF POLYVALENT ANTIMENINGOCOCCUS SERUM PRODUCED WITH FOUR AND SIX REPRESENTATIVE STRAINS AND THAT PRODUCED WITH SIXTY STRAINS, AS DETERMINED BY THE AGGLUTINATION TITER
title_full_unstemmed COMPARISON OF THE POTENCY OF POLYVALENT ANTIMENINGOCOCCUS SERUM PRODUCED WITH FOUR AND SIX REPRESENTATIVE STRAINS AND THAT PRODUCED WITH SIXTY STRAINS, AS DETERMINED BY THE AGGLUTINATION TITER
title_short COMPARISON OF THE POTENCY OF POLYVALENT ANTIMENINGOCOCCUS SERUM PRODUCED WITH FOUR AND SIX REPRESENTATIVE STRAINS AND THAT PRODUCED WITH SIXTY STRAINS, AS DETERMINED BY THE AGGLUTINATION TITER
title_sort comparison of the potency of polyvalent antimeningococcus serum produced with four and six representative strains and that produced with sixty strains, as determined by the agglutination titer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128163/
https://www.ncbi.nlm.nih.gov/pubmed/19868475
work_keys_str_mv AT wadsworthaugustusb comparisonofthepotencyofpolyvalentantimeningococcusserumproducedwithfourandsixrepresentativestrainsandthatproducedwithsixtystrainsasdeterminedbytheagglutinationtiter

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